摘要
NLRs及其形成的多蛋白水解复合物—炎症小体,作为炎症反应的核心,被各种外源或内源的刺激通过不同的信号通路激活,进而诱导caspase-1分子活化,引起IL-1β、IL-18、IL-33等促炎细胞因子分泌,在肾脏炎症反应过程中发挥重要作用。本文就炎症小体的结构、活化信号、激活通路及对肾脏疾病作用的近期研究作一综述。
NLRs and the formation of multiprotein proteolytic complexes—inflammasomes,as the core of the inflammatory response,activated by various exogenous or endogenous stimuli through different signaling pathways,thereby induce activation of caspase-1 molecules and secretion of inflammatory cytokines,such as IL-1β、IL-18、IL-33,play an important role in the process of renal inflammation.Here we review the current knowledge regarding the structure、triggers and pathway of activation,and functional role of the inflammasomes in kidney disease.
出处
《当代医学》
2012年第3期31-33,共3页
Contemporary Medicine
