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活性氧簇及抗氧化治疗与糖尿病肾病 被引量：1

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摘要 糖尿病肾病(DN)是最严重的糖尿病并发症之一。目前,越来越多的证据证明了活性氧簇(ROS)在DN的发生和发展中扮演着重要的角色。本文简述了DN中ROS调节的信号通路,包括高糖介导ROS产生的机制、ROS活化信号转导通路、ROS与糖尿病肾脏基质的重构;抗氧化治疗对DN作用的评价以及ROS在DN发病机制中有争议的观点等几个问题。糖尿病患者体内存在的多种代谢紊乱都会导致氧化应激、ROS增加,使一些信号通路如丝裂原活化蛋白激酶(MAPK)通路活化增加而导致DN的发生和发展。这为抗氧化治疗是否能成为预防和治疗DN的新策略提供了一定依据。
作者 钟海花 徐勇
机构地区 泸州医学院附属医院内分泌科
出处 《国外医学（内分泌学分册）》 2005年第B04期32-34,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 活性氧簇 抗氧化治疗 糖尿病肾病 并发症
分类号 R587.2 [医药卫生—内分泌]
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参考文献18

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同被引文献21

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国外医学（内分泌学分册）
2005年 第B04期

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