摘要
目的:研究复尔康胶囊对小鼠移植肿瘤的抑制作用和对多种肿瘤化疗药物的增效作用。方法:测定高、中、低剂量复尔康胶囊(500、250、125mg.kg-1)对小鼠移植肿瘤S180、H22、Lewis的抑瘤率;并将复尔康胶囊与不同作用机制的肿瘤化疗药物(丝裂霉素、氟尿嘧啶、顺铂、平阳霉素、羟喜树碱、阿霉素)合用,测定其对小鼠移植肿瘤S180、H22、Lewis的抑瘤率。结果:复尔康胶囊对3种小鼠移植肿瘤均有显著抑制作用(P<0.01),与肿瘤化疗药物合用对小鼠移植肿瘤S180、H22、Lewis的抑瘤率比单用肿瘤化疗药物效果更好(P<0.05)。结论:复尔康胶囊不但具有明显的抗肿瘤作用,而且对不同作用机制的肿瘤化疗药物具有显著的增效作用。
OBJECTIVE： To study the inhibitory effects of Fuerkang capsule on mice transplanted tumors and Fuerkang cap- sule＇ s synergy effects when combined with different chemotherapeutic drugs. METHODS： The inhibition rates of high-dose, medi- um-dose and low-dose of Fuerkang capsules （500, 250, 125 mg.kg^-1） on S180,H22 and Lewis tumors were all determined. Fuerkang capsule was also combined with different chemotherapeutic drugs of varies pharmaceutical mechanisms （mitomycin, fluorouraciI, cisplatin, peplomycin, hydroxycamptothecin, adriamycin） and inhibition rates of S180, Hz2 and Lewis tumors were measured. RESULTS： Fuerkang capsule showed significant inhibitory effects on three different tumors （P〈0.01）. Inhibitory effects of Fuerkang capsule combined with chemotherapeutic drugs on St88, Hz2 and Lewis tumors were better than chemotherapeutic drugs alone （P〈 0.05）. CONCLUSION： Fuerkang capsule has not only anti-tumor effects, but also can generate synergy effects when combined with chemotherapeutic drugs.
出处
《中国药房》
CAS
CSCD
2012年第3期197-199,共3页
China Pharmacy
基金
黑龙江省科技计划项目(GC09C407-3)
关键词
复尔康胶囊
抗肿瘤
增效
Fuerkang capsule
Anti-tumor
Synergy
