摘要
目的 :研究人参皂苷 Rh1及其前体 Rg1的整体及离体抗肿瘤作用。方法 :整体实验 4种小鼠移植性肿瘤 :小鼠宫颈癌 - 1 4( U14 )、艾氏腹水癌 ( EAC)、肉瘤 - 1 80 ( S180 )和肝癌腹水型 ( Hep A)腋部皮下接种 ,于接种 1 0 d内 ,每天给药 1次 ,计算各给药组肿瘤抑制率。离体抗肿瘤实验用 3种瘤株 :A375 - S2、T98G 和 He La。结果 :人参皂苷 Rg1( 2 0 0 mg·kg-1,灌胃 )和 Rh1( 4 0和2 0 mg· kg-1,腹腔注射 )对 U14 均具有明显的抑制作用 ( P<0 .0 1 ) ;人参皂苷 Rh1在较高剂量( 4 0 mg·kg-1)时 ,对 EAC也有明显抑制作用 ( P<0 .0 1 )。但人参皂苷 Rg1和 Rh1对 S180 和 Hep A无抗肿瘤作用。离体实验证明 ,Rg1对 He La细胞的增殖有明显的抑制作用 ,Rh1高剂量组( 1 0 0 mg· L-1)对 3种肿瘤细胞均有明显抑制作用。结论 :人参皂苷 Rh1较其前体
Objective: To study the effect of ginsenoside Rh 1 and Rg 1 on the experimental tumor strains in vivo and in vitro.Methods: Carcinoma of uterine cervix (U 14 ), Ehrlich ascites carcinoma (EAC),sarcoma 180 (S 180 ) and hepatic carcinoma of ascitic type (HepA) were used for anti tumor cell studies in vivo. A375 S2,T98G and HeLa tumor strains were used for anti tumor experiment in vitro. Results: Rg 1 (200 mg· kg -1 , ig ) and Rh 1(20 and 40 mg· kg -1 , ip ) exhibited significant inhibitory effect on U 14 , and the bigger dosage of Rh 1 showed obvious anti tumor activity for EAC. However, the both of Rg 1 and Rh 1 had no affection on S 180 and HepA. Rh 1 exhibited obviously inhibitory effect on the three tumor cell strain′s proliferations. Conclusion: Rh 1 possesses stronger anti tumor activity than its prodrug Rg 1.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2003年第1期25-28,共4页
Journal of Jilin University：Medicine Edition
基金
国家自然科学基金资助课题 (395 70 86 1)
