摘要
目的探讨支气管哮喘患儿血清白细胞介素-4（IL-4）和干扰素-γ（IFN-γ）与支气管哮喘的关系及临床意义。方法收集2010年1月至2010年12月在我院就诊的支气管哮喘患儿50例（哮喘组），采用双抗体夹心酶联免疫吸附方法（ELISA）测定血清IL-4和IFN-γ水平，并选取性别和年龄相匹配的20例健康体检儿童作为对照（对照组），比较两组间血清IL-4和IFN-γ水平的差异。结果哮喘组患儿血清IL-4浓度显著高于正常对照组，哮喘组血清IFN-γ浓度显著低于正常对照组（P均〈0．05）。结论支气管哮喘患儿IL-4水平升高，而IFN-γ水平下降，说明支气管哮喘患儿存在细胞免疫失衡；血清IL-4和IFN-γ浓度检测可以做为支气管哮喘患儿的辅助诊断手段，并为支气管哮喘的治疗提供依据。
Objective To investigate the corelation of serum IL -4 and IFN -γ in childhood with asthma and their clinical significance. Methods A total of 50 children with bronchial asthma were collected in our hospital from Jan. 2010 to Dee. 2010（ asthma group）. Twenty cases of gender and age -matched healthy children were selected as the control group, the concentration of serum IL - 4 and IFN - γ were detected by enzyme- linked immunosorbent assay （ELISA） and compaired between the two groups. Results The serum IL -4 concentration of asthma group was significantly higher than that of control group, the serum IFN - γ concentration of asthma group were lower than that of control group （P 〈 0.05 ）. Conclusions The concentration of IL -4 was higher and IFN -γ was lower in children with asthma than that in control group, indicating that the balance of cell immune is destructed in children with asthma; IL-4 and IFN-γ test may be used as a diagnostic method for asthma.
出处
《中国实用医刊》
2012年第1期21-22,共2页
Chinese Journal of Practical Medicine
