摘要
目前,支气管哮喘的发病机制还不十分清楚,可能与遗传、免疫、环境等有关。其中,哮喘与免疫的关系已经成为研究重点。哮喘的发病从免疫学角度可以分为三期:初期为致敏阶段,与T细胞激活关系密切,B7/CD28和CD69在这一过程也扮演重要角色;第二期为慢性过敏性炎症阶段,TH1/TH2失衡导致免疫功能紊乱是此阶段的主要原因,在哮喘发作过程中起主要作用;第三期为慢性炎症引起的气道结构重构阶段,是难治性支气管哮喘的重要发病和死亡原因。针对不同阶段分析哮喘与免疫关系,将为深入研究哮喘的发病机制提供新的思路。
The pathogenesis of bronchial asthma, which may relate to heredity, immunity and environment, has not yet been clearified. Nowadays, the relationship between asthma and immunity has become the focus. The pathogenesis of asthma can be divided into three stages in immunology. The initial stage is sensibilization, which is closely associated with the activation of T cells. B7/CD28 and CD69 also play a significant role in this process. The second stage is chronic allergic inflammation. The immune dysfunction resulting from the disturbance of TH1/TH2 is a major cause of chronic allergic inflammation, and dominates asthma attack. And the third stage is airway remodeling due to chronic inflammation. Airway remodeling is one of the major causes of refractory asthma, which also contributes to the death from asthma. Research on relationship between asthma and immunology at different stages of asthma provides a new idea for the research of pathogenesis of asthma.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2009年第5期602-606,共5页
Journal of Shanghai Jiao tong University:Medical Science
关键词
支气管哮喘
免疫学
T细胞
抗原递呈细胞
转录因子
bronchial asthma
immunology
T cell
antigen presenting cell
transcription factor
