摘要
生殖器疱疹(genital herpes,GH)是最常见的性传播性疾病之一,大部分由人单纯疱疹病毒(herpes simplex virus,HSV)-2所致、少部分由HSV-1所致,既可感染邻近黏膜细胞、淋巴和(或)血行感染其它部位,也可感染外周神经系统。GH表现为原发性生殖器疱疹、复发性生殖器疱疹和亚临床HSV激活,对精神并发症、宫颈癌发病和艾滋病病毒感染有重要影响。实验室检测对GH的确诊有一定价值,以型特异性血清检测更常用。目前常用的抗HSV药物主要有阿昔洛韦、伐昔洛韦和法昔洛韦,应系统治疗和局部治疗相结合。系统治疗主要以抗病毒治疗为主,可分为间歇疗法和长期抑制疗法。
Genital herpes （GH） is one of the commonest sexually transmitted diseases largely caused by human herpes simplex virus （HSV） -2 and partially by HSV-1. It generally infects adjacent mucosa ceils, lymph nodes, remote parts by blood vessels and peripheral nervous system. Its manifestation includes primary GH, recurrent GH and subclinical HSV activation. The disease plays an important impact on the attack of mental complication, cervical carcinoma and HIV infection. Lab tests are valuable for confirmation of GH. The type-specific blood test is more available. Currently, the conventional anti-HSV medicines include acyclovir, valaciclovir and famciclovir. Systemic medications combined with topical treatments are routinely recommended, in which systemic medication is mainly antiviral therapy including intermittent and suppressive treatment.
出处
《上海医药》
CAS
2012年第1期4-7,共4页
Shanghai Medical & Pharmaceutical Journal
