摘要
目的:探讨基质金属蛋白酶-7(MMP-7)和肝细胞生长因子(HGF)在白血病患者中的表达及两者的相关性。方法:采用酶联免疫法(ELISA)检测了50例白血病患者和40例健康对照组外周血中MMP-7和HGF的表达。及经两个疗程标准化疗后50例白血病患者中HGF及MMP-7的表达。结果:HGF和MMP-7在白血病组的表达水平高于对照组,且差异有显著性(P均<0.05),两者之间呈正相关性(r=0.303,P<0.05)。HGF与MMP-7在白血病各分型中的表达无差异(P>0.05),初治组与复发组之间HGF与MMP-7的表达差异无统计学意义(P>0.05)。HGF与MMP-7在白血病完全缓解组(CR)的表达水平明显低于未完全缓解组(PR)(P<0.05)。结论:HGF与MMP-7的高表达可能与白血病的发生发展发病相关。HGF和MMP-7在白血病的早期诊断与治疗中也起到了重要的作用。
Objective： To investigate the expression of MMP-7 and HGF in leukemia and the relationship between the expression and leukemia in the peripheral blood of leukemia. Methods：The expression of MMP-7 and HGF was detected in 50 cases of leukemia and 40 healthy controls by enzyme league immune method （ELISA）, and the same to the expression after two courses of chemotherapy. Results：The levels of MMP-7 and HGF in peripheral blood in leukemia were higher than those in healthy adults （P 〈 0.05）, with a significant difference （P〈 0.05） and a positive correlation （r = 0. 303,P 〈 0.05） between the MMP--7 expression and the HGF expression. There was no difference in the different types of leukemia between the HGF expres- sion and the MMP--7 expression （P 〉 0.05） as well as no difference in the HGF and the MMP--7 expression between the untreated group and the recurrent group （P 〉 0.05）. The expression levels of MMP--7 and HGF in the CR group was lower than those in the PR group, with a significant difference （P 〈 0.05）. Conclusion ： Higher expression levels of HGF and MMP--7 may play an important role in the peripheral blood in leukemia. Combined analyses of the expression of HGF and MMP--7 may be useful in evaluating the prognosis and treatment of leukemia.
出处
《黑龙江医药科学》
2011年第6期36-37,共2页
Heilongjiang Medicine and Pharmacy
