摘要
目的:探讨当归芍药散配伍对主要入血成分药动学的影响规律。方法:将当归芍药散分为白芍组(S)、归-芎组(DC)、芍-归-芎组(SDC)和全方组(DSS)。大鼠分别灌胃各组提取物,采用HPLC测定血浆中芍药内酯苷、芍药苷、阿魏酸和藁本内酯的含量,计算并比较各组药动学参数。结果:归-芎组与白芍配伍后使芍药苷和芍药内酯苷出现了多重吸收的过程,全方组中多重吸收现象消失,Tmax和MRT缩短,AUC降低。白芍与归-芎组配伍降低了阿魏酸的Cmax,Tmax,MRT和AUC,全方组较芍-归-芎组除AUC提高外无明显区别。白芍降低了归-芎组藁本内酯Cmax和AUC,与芍-归-芎组相比,全方组的MRT缩短,AUC增加。结论:方中臣药归-芎对君药白芍成分的影响体现在多重吸收的现象,君药对臣药成分的影响为显著降低血药浓度水平和生物利用度。佐使药对芍-归-芎组中君药成分影响较大,使其消除速度加快,生物利用度降低。
Objective：To investigate the effects of compatibility of Danggui-Shaoyao-San（DSS） on the pharmacokinetics of its major components in rats.Method：The entire formula is divided into four groups：Paeoniae Radix Alba（S）,Angelica Sinensis Radix-Chuanxiong Rhizoma（DC）,Paeoniae Radix Alba-Angelica Sinensis Radix-Chuanxiong Rhizoma（SDC） and entire formula.The extract of each group was given to rats orally,and albiflorin,paeoniflorin,ferulic acid and ligustilide in rat plasma were determined by HPLC.Result：Combination of S and DC lead a multi-absorption process to albiflorin and paeoniflorin.In DSS their multi-absorption disappeared,with Tmax,MRT and AUC decreased.Compatibility of S with DC reduced the Cmax,Tmax,MRT,and AUC of ferulic acid,while there was no significant differences in DSS expect an increased Cmax as compared with SDC.Combination of S and DC sharply decreased Cmax and AUC of ligustilide,while its MRT and AUC were increased in DSS.Conclusion：The main effect of DC to S was leading to a multi-absorption of albiflorin and paeoniflorin,which maintained a relatively high plasma level in longer time.Combination of S with DC greatly decreased plasma level and bioavailability of ferulic acid and ligustilide.Assistant and guide drugs mainly affect albiflorin and paeoniflorin in SDC,which accelerated their absorption and elimination rates,and lower their bioavailability.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第1期121-124,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(30873322)
江苏高校优势学科建设工程项目
关键词
当归芍药散
配伍
药代动力学
Danggui-Shaoyao-San
compatibility
pharmacokinetics
