摘要
目的 观察国产吉西他滨联合奥沙利铂（GEMOX方案）对复发或难治性非霍奇金淋巴瘤的近期疗效和毒副反应.方法 对28例复发或难治性非霍奇金淋巴瘤患者,采用国产吉西他滨1 000 mg/m2 d1,d8,静脉滴入;奥沙利铂130 mg/m2 d1,静脉滴入;3周为1个化疗周期.每2周期评价疗效.结果 28例患者均可评价疗效,19例获得缓解,占67.8%,其中CR 8例（28.6%）;PR 11例（39.2%）;13例具有B类症状的患者中9例症状消失,4例明显改善.化疗毒副反应主要为骨髓抑制,治疗后均得以改善.结论 GEMOX方案对复发或难治性非霍奇金淋巴瘤有较好的近期疗效,且副反应可耐受,是一个值得进一步验证的补救性化疗方案.
Objective To evaluate the effect and toxicity of gemcitabine combined with oxaliplatin in the treatment of patients with relapsed or refractory of non - Hodgkin＇s lymphoma. Methods twenty - eight patients with histologically confirmed relapsed or refractory non -Hodgkin＇s lymphoma were enrolled in this study. The chemotherapy regimen consisted of gecitabine（ 1 000 mg/m2 d1,8 ） ,oxaliplatin（ 130 mg/m2 d1）given every three weeks. Their clinical response was assessed after 2 cycles of chemotherapy. Results In the 28 patients, 19 pa- tients（ 67.8% ）showed response including 8 patients complete response and 11 patients partial response. Nine patients＇symptoms disappeared, and 4 in 13 patients were alleviated of type B symptoms. Drug related toxic effects was bone narrow depression. Conclusions GEMOX regimen possesses better short - term efficacy, acceptable toxicity. This protocol is worthy to warranted as salvage for relapsed or refractory non - Hodgkin＇s lymphoma.
出处
《实用肿瘤学杂志》
CAS
2011年第6期547-550,共4页
Practical Oncology Journal
