摘要
目的:观察泽菲(盐酸吉西他滨,gemcitabine)联合奥沙利铂(oxaliplatin,LOHP)和地塞米松(DXM)对复发性或难治性进展型非霍奇金淋巴瘤(nonHodgkin’slymphoma,NHL)的疗效和毒副反应。方法:泽菲1000mg/m2,静脉滴入,d1、d8;LOHP85mg/m2,静脉滴入,d1、d8;DXM40mg/d,静脉推注,d1～d4。以3～4周为1个化疗周期。20例复发性或难治性进展型非霍奇金淋巴瘤患者,治疗≥3个周期。结果:20例患者中,15例获得缓解,占75.0%。其中完全缓解(CR)7例,部分缓解(PR)8例。7例具有B类症状的患者中,4例症状消失,2例明显改善,1例无改善。化疗毒副反应主要为轻度的胃肠道反应,少数患者出现轻度的骨髓抑制,如白细胞及血小板减少。结论:泽菲联合LOHP和DXM对复发性或难治性进展型NHL有较好的近期疗效,能明显改善患者症状,且大部分患者可以承受其毒性,是一个值得进一步验证的补救性化疗方案。
OBJECTIVE： To evaluate the effect and toxicity of gemcitabine combined with oxaliplatin and dexamethasone in the treatment of patients with relapsed or refractory of non Hodgkin＇s lymphoma. METHODS： Twenty patients with histologically confirmed relapsed or refractory non Hodgkin＇s lymphoma were enrolled in this study. The chemotherapy regimen con sisted of gemcitabine （1 g/m^2 , days 1 and 8）, oxaliplatin （85 mg/m^2 , days 1 and 8） and dexamethasone （40 mg/d, day 1-4） given every three to four weeks. RESULTS： Of 20 patients, 15 patints （75 %） showed response including 7 patients having complete response and 8 patients partial response. Four patients＇ symptoms disappeared, and 2 in 7 patients were alleviated of type B symptoms. Drug related toxic effects were mild gastrointestinal reactions in most patients and mild bone marrow depression in few patients such as neutropenia, thrombocytopenia. CONCLUSIONS： The combination of gemcitabine, oxaliplatin and dexamethasone possesses better short-term efficacy, acceptable toxicity, and obvious alleviation of symptoms related to the disease. This protocol is worthy to be warranted as salvage for relapsed or refractory non Hodgkin＇s lymphoma.
出处
《肿瘤防治杂志》
2005年第23期1814-1816,共3页
China Journal of Cancer Prevention and Treatment
