摘要
应用壳聚糖与甲基丙烯酸甲酯(MMA)通过自由基聚合反应,以硝酸铈铵为引发剂合成一种功能新颖的药用纳米粒子,作为药物的载体材料,与药物结合后可以调节药物释放速度,减少给药次数,从而增加药物治疗的安全性、高效性和可靠性。研究结果表明,硝酸铈铵可以较好地引发接枝反应,当反应温度为50℃,反应时间为4h,壳聚糖0.6g、甲基丙烯酸甲酯6mL、硝酸铈铵0.9g、1%醋酸300mL时,合成的纳米粒粒径最小,平均粒径在179nm左右。体外溶出实验表明,当n(阿司匹林)∶n(壳聚糖)=1∶1时,制备出的纳米粒载药量、包封率较高,可达72.1%,载药纳米粒在16h内对药物有良好的缓释作用,具有较好的应用前景。
Chitosan and methyl methacrylate（MMA） were prepared into novel-functional medical nanoparticles through radical polymerization.Nanoparticles loaded with medicine can regulate degree of releasing,and reduce deliver time,in order to increase safety,high-effect and dependment of medication as a carrier material of medicine.It is showed that ammonium ceric nitrate is a good initiator in graft reaction.The grain diameter of compounded nanoparticle is minimized into 179 nm on average when temperature is 50 ℃,reacting time 4 h,chitosan 0.6 g,MMA 6 mL,ammonium ceric nitrate 0.9 g,and 1% acetic acid 300 mL.The vitrorelease test shows that the drug-loading rate and envelop rate is up to 72.1%,and nanoparticles works well in sustained-releasing medicine when the proportion of aspirin and chitosan reaches 1∶1.
出处
《青岛科技大学学报（自然科学版）》
CAS
2011年第6期551-555,共5页
Journal of Qingdao University of Science and Technology:Natural Science Edition
基金
青岛市应用基础研究计划项目(09-1-3-17-jch)
国家海洋局海洋溢油鉴别与损害评估技术重点实验室开放基金项目(201014
201104)
关键词
壳聚糖
接枝共聚
纳米粒
硝酸铈铵
药物缓释
chitosan
graft copolymerization
nanoparticles
ammonium ceric nitrate
sustained-release
