摘要
目的： 研究诺迪康对大鼠心肌缺血、血脂及脂蛋白的影响。方法： 结扎大鼠左冠状动脉造成急性心肌缺血模型， 以∑ＳＴ 和ＮＳＴ 来反映心肌缺血程度和范围， 用Ｎ－ ＢＴ 染色确定心肌梗塞面积。用高脂饲料复制高脂血症大鼠模型， 连续灌胃给药１０ 天后测定血清ＴＧ、ＴＣ、ＨＤＬ－ Ｃ，计算ＬＤＬ－ Ｃ。结果和结论：诺迪康可降低大鼠实验性心肌缺血程度和缺血范围，减少梗塞面积；也能降低高脂血症大鼠ＴＧ 、ＴＣ、ＬＤＬ－ Ｃ，而升高ＨＤＬ－ Ｃ。
AIM:To study the effects of Nuo Di Kang on myocardial ischemia and blood-lipid and lipoprotein in rats. METHODS:Acute myocardial ischemia model was performed with left anterior descending(LAD)occlusion in rat heart.∑st and Nst of electrocardiograph(ECG)were used to evaluate the degree and range of myocardial ischemia,respectively.Myocardial infarction area was determined by N-BT stain.By the way of feeding high-lipid diet to Wister tars,hyperlipidemic rats model was made.Total serum TC,TG,HDL-C contents and LDL-C content were measured.RESULTS & CONCLUSION:Nuo Di Kang could reduce myocardial ischemia degree and myocardial infarction area in experimental ischemia rat hearts and could reduce TC,TG,LDL-C but increase HDL-C in hyperlipidemic rats.
出处
《中国药房》
CAS
CSCD
2000年第1期16-17,共2页
China Pharmacy
关键词
诺迪康
红景天
心肌缺血
地奥心血康
药理
Nuo Di Kang
Rhodiola Sacra
myocardial ischemia
propranolol
hyperlipidemia
lipoprotein
Diao Xinxuekang
