摘要
本文对治疗药物监测的药物如中药、抗癫痫药、免疫抑制药、抗逆转录病毒药物、抗精神病药物、抗肿瘤药物和抗微生物药物的最新研究进展进行综述,介绍其方法学上的最新进展,如利用液质联用将成为发展方向。结合群体药动学和药物遗传学的最新发展,研究疾病药物治疗中的新方法,指导临床个体化用药,提出治疗药物监测(TDM)新的发展方向,如利用基因分型和基因芯片对患者测定基因型,以指导临床合理用药。
In this article,the recent progresses on therapeutic drug monitoring which involves those drugs such as traditional Chinese medicine,antiepileptic drugs,immunosuppressive drugs,antiretroviral drugs,antipsychotic drugs,antitumor drugs and anti-microbial drugs were reviewed.The latest development of methodology was described,and the use of LC-MS will be the development direction.Combined with the latest developments of population pharmacokinetic and pharmacogenetic,new methods for individualized medicine were developed,and new development directions for therapeutic drug monitoring were proposed,such as use of genotyping and gene chips to identify the genotype for personalized medicine.
出处
《中国药物应用与监测》
CAS
2011年第6期379-382,共4页
Chinese Journal of Drug Application and Monitoring
基金
北京市自然科学基金资助项目(7113157)
首都医科大学基础临床合作课题(09JL10)
关键词
治疗药物监测
个体化用药
群体药动学
Therapeutic drug monitoring
Individualized medicine
Population pharmacokinetic
