摘要
目的探讨卡铂、多西他赛及吉西他滨联合疗法治疗复发性卵巢癌的疗效及不良反应。方法将笔者所在医院随访发现卵巢癌复发的45例患者随机分为试验组和对照组,试验组采用卡铂、多西他赛及吉西他滨联合治疗,对照组采用顺铂联合吉西他滨治疗。观察比较两组患者治疗后近期总有效率、中位生存期及不良反应。结果试验组近期总有效率、中位生存期、骨髓抑制率均显著高于对照组(P<0.05),对照组消化道不良反应发生率显著高于试验组(P<0.05)。结论卡铂、多西他赛及吉西他滨联合疗法对于复发性卵巢癌的治疗具有更好的疗效,与传统疗法相比,并未增加安全风险。
Objective To discuss the efficacy and side effects of therapy of carbeplatin combined with decetaxel and gemcitabine in treatment of recurrent ovarian cancer. Methods 45 cases of recurrent ovarian cancer diagnosed through followed - up visit in the hospital were randomly assigned to receive carbopiatin combined with docetaxel and gemcitabine（ experimental group） or cisplatin and gemcitabine（ control group）. Recent total efficiency, the median survival time and side effects were observed and analyzed. Results Total efficiency, median survival time and rate of bone marrow suppression in experimental group were significantly higher than those of control group（ P 〈 0. 05 ）, the incidence of gastrointestinal adverse reac- tions in control group was significantly higher than the experimental group （ P 〈 0. 05 ）. Conclusion The therapy of carbeplatin combined with docetaxel and gemcitabine has a better efficacy compared with conventional therapy, and good safety.
出处
《中国医学创新》
CAS
2011年第36期26-28,共3页
Medical Innovation of China
关键词
复发性卵巢癌
卡铂
多西他赛
吉西他滨
Recurrent ovarian cancer
Carbeplatin
Docetaxel
Gemcitabine
