摘要
[目的 ] 了解Mh对喹喏酮类药物的耐药状况 ,指导合理使用抗生素。 [方法 ] 将标准株与敏感株分别进行诱导耐药与交叉耐药试验。 [结果 ] 氧氟沙星、左旋氧氟沙星、盐酸环丙沙星诱导的Mh对氧氟沙星、左旋氧氟沙星、盐酸环丙沙星、司帕沙星均产生耐药。司帕沙星诱导耐药的Mh对氧氟沙星、盐酸环丙沙星、左旋氧氟沙星无明显交叉耐药。 [结论 ] Mh长期接触低浓度喹诺酮类药物会诱导产生耐药性 ,而且大多数呈现稳定耐药与交叉耐药。
Objective] To acquire the information about the present resistance characteristics in Mycoplasma hominis(Mh), especially in Quinolones, and to instruct reasonable application of antibiotics clinically. [Methods] A total of 5 isolates Mh from clinical specimens and 1 standard strain were induced resistance and cross-resistance. [Results] OFX-resistant Mh showed cross-resistance to LFX and CFX and SFX. Similarly, LFX-resistance Mh cross-resistance to OFX and CFX and SFX, CFX-resistance Mh cross-resistance to OFX and LFX and SFX. However, SFX-resistance Mh did not appear cross-resistance to OFX and LFX and CFX. [Conclution] The strains of Mh can produce resistant and corss-resistant characteristics when they long time contact with antibiotic subinhibitory concentraction of Quinolones.
出处
《实用预防医学》
CAS
2000年第1期12-14,共3页
Practical Preventive Medicine
基金
湖南省科委资助
关键词
人型支原体
喹诺酮类药物
交叉耐药
Mycoplasma hominis(Mh), Cross-Resistance, Quinolones.
