摘要
研究大豆黄酮对D–半乳糖致衰老小鼠脑神经递质水平的调节.连续背部注射D–半乳糖6周,建立衰老模型,然后灌胃大豆黄酮5周(实验组Ⅰ、Ⅱ的剂量分别为5、10 mg/(kg.d)),监测不同脑区乙酰胆碱、乙酰胆碱酯酶、多巴胺和5–羟色胺含量变化,探讨大豆黄酮对衰老小鼠脑组织神经递质水平的影响.结果表明,灌胃衰老小鼠大豆黄酮后,大脑皮质和海马中乙酰胆碱、乙酰胆碱酯酶、多巴胺和5–羟色胺含量明显上升,并且具有一定的剂量效应.说明大豆黄酮可以改善衰老小鼠脑组织中神经递质含量,具有明显的抗衰老作用.
To observe daidzein on the effects of D-galactose induced senescence in mice,D-galactose was injected in the dorsal of mice for 6 weeks as an aged model.The aged mice were fed daidzein with the doses 5 mg/（kg.d）（Test Ⅰ）and 10 mg/（kg.d）（Test Ⅱ）for 5 weeks.The levels of acetylcholine,acetylcholinesterase,dopamine,and 5-hydroxytryptamine in brain of the aged mice were examined.The results showed that daidzein could increase acetylcholinea,cetylcholinesterase,dopamine,and 5-hydroxytryptamine levels in cortex and hippocampus of aged mice.Daidzein could increase neurotransmit-ter levels of the mice’s brain and have antisenecence in some degree.
出处
《天津科技大学学报》
CAS
2011年第6期16-19,共4页
Journal of Tianjin University of Science & Technology
基金
天津市海洋资源与化学重点实验室开放基金课题(200913)
天津科技大学引进人才科研启动基金资助项目(20100410)
