摘要
目的调查郴州市某三甲医院婴幼儿支气管肺炎患儿抗生素的使用情况,并对其疗效进行初步评价。方法选择郴州市某三甲医院婴幼儿支气管肺炎(无合并症)住院患儿242例,对其抗生素使用情况进行回顾性调查,并对不同的抗生素用药组运用Kaplan-Meier法进行时间效应分析。结果 242例婴幼儿支气管肺炎患儿共使用14种抗生素,使用最多的为β内酰胺类抗生素,其中的苯唑青霉素和头孢地嗪钠的使用占到总频数的19.8%和18.6%。大环内酯类抗生素阿奇霉素使用也较多,占到总频数的21.1%。用药以单用抗生素为主(83.5%)。Kaplan-Meier分析,结果显示不同用药组平均治愈时间比较差异有统计学意义(P<0.05)。结论目前治疗婴幼儿支气管肺炎以β内酰胺类抗生素为主,阿奇霉素也得到了广泛应用。高效、广谱抗生素的广泛使用应引起重视。Kaplan-Meier分析可更全面地评价不同药物的疗效。
Objective To investigate the current situation of antibiotics use in the treatment of infantile bronchial pneumonia in a grade three class A hospital in Chenzhou with the hope to evaluate the curative effects of different drugs. Methods A total of 242 infant bronchial pneumonia inpatients （ without complications）, in a grade three class A hospital in Chenzhou were selected, with the use of antibiotics in these patients retrospectively studied. Time - effect analysis for different antibiotics was done using Kaplan - Meier method. Results Fourteen kinds of anti - bacterium drugs were used in 242 cases of infant bronchial pneumonia （without complications）, among which β - lactam antibiotics were mostly used. The use of oxacillin and eefoclizime sodium accounted for 19. 8% and 18. 6% of total frequency respectively. The use of azithromycin was also frequent （21.1%）. Most cases （831 5% ） employed only one kind of antibiotics. The effect of oxaciUin was better than others in treating infant bronchial pneumonia according to Kaplan - Meier analysis, Conclusion β - lactam antibiotics are the most commonly used drug in treating infant bronchial pneumonia; azithromycin is also frequently used. The use of strong, broad spectrum antibiotics calls for more attention. Kaplan - Meier analysis could be used in the comprehensive evaluation of drug efficacy.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第36期4180-4182,共3页
Chinese General Practice
关键词
支气管肺炎
抗菌药
Β内酰胺类
Bronchopneumonia
Anti - bacterial agents
Beta - lactams
