摘要
目的本研究观察新生儿感染性肺炎常用的抗生素的疗效以及抗生素对肠道微生态的影响。方法以新生儿感染性肺炎患者为研究对象,按抗生素的使用不同而分组,以各项观察项目全部正常的时间作为肺炎病程终止时间,比较各观察组的治愈率并进行时间——效应分析。分析使用抗生素3天、7天时肠道菌群中细菌的含量,以了解抗生素对肠道菌群影响情况。结果①青霉素组、头孢组、联合用药组的治愈率以及时间-效应分析的结果无显著性差异；②使用抗生素对新生儿肠道菌群有影响,其影响随着抗生素使用时间的增加而增大；③三个观察组对肠道微生态的影响以青霉素与头孢菌素联合使用组最为明显、头孢菌素组次之、青霉素组最小。
Objective To explore the effect of antibiotics to neonatal intestinal microflora. Methods the neonatus who had infectious pneumonia were selected as case - groups,and divided into three sub - groups according to the antibiotics the patient used randomly. Taking the period when all indexes were normal as pneumonia being cured,and curing rate and time - effect were compared among groups. To explore the effect of antibiotics to neonatal,the main microflora which can reflect the all intestinal microflora were quantitatively analysed when antibiotics had been used three and seven days respectively. Results The results showed that：①there is no significant difference on curing rate and time - effect among the three groups;②antibiotics showed effect to neonatal intestinal microflora, and the longer the antibiotics was used,the more significant the effect was;③the group with penicillin and cynnematin simultaneously showed the most effect to intestinal microflora,and the group with cynnematin only showed moderate effects on intestinal microflora, and the group with penicillin showed little effect to intestinal microflora.
出处
《医学研究杂志》
2006年第10期61-63,共3页
Journal of Medical Research
