摘要
目的：研究肠内营养（ＥＮ）支持对ＩＣＵ 患者的细胞免疫功能的影响。方法：对１１ 例健康人和１２ 例ＩＣＵ 患者经ＥＮ 支持前后的细胞免疫功能进行检测。结果：ＩＣＵ 患者的细胞免疫功能明显低于健康人，表现为自然杀伤（ＮＫ）细胞活性和Ｔ细胞亚群ＣＤ４、ＣＤ４ ／ＣＤ８ 明显降低（Ｐ＜ ０．０１ 或Ｐ＜ ０．０５）。经一段时期的ＥＮ 支持后，细胞免疫功能有明显回升，表现为ＣＤ３、ＣＤ４ 、ＣＤ４ ／ＣＤ８ 和ＮＫ细胞活性明显升高（Ｐ＜ ０．０５ 或Ｐ＜ ０．０１），白介素 α（ＩＬ α）浓度及ＩＬ ２ 分泌细胞明显升高（Ｐ＜ ０．０１ 或Ｐ＜ ０．０５）。结论：肠内营养支持可以显著改善ＩＣＵ 患者的细胞免疫功能。
Objective:To investigate the effect of enteral nutritional (EN) support on cellular immunity in ICU patients.Methods: 11 ICU patients received EN support,12 healthy volunteer served as control group.Interleukin2 (IL2) and Tcell subpopulations (CD 3,CD 4,CD 8) were measured before and after EN support.Results:It was found that immunosuppression was present in ICU patients in the form of marked decrease in NK activity and CD 4,as well as CD 4/CD 8 ratio ( P <0 05 or P <0 01).However,cellular immune function was marked improved in patients after treatment with EN.NK activity,IL2 activity,IL2 secreted cells,and CD 3,CD 4,as well as CD 4/CD 8 ratio were significantly elevated ( P <0 05 or P <0 01).Conclusions:EN support might improve cellular immune function in ICU patients.
出处
《中国危重病急救医学》
CAS
CSCD
2000年第2期113-115,共3页
Chinese Critical Care Medicine
关键词
危重症患者
肠内营养
T细胞亚群
IL-2
细胞免疫
ICU patients
enteral nutrition
Tcell subpopulation
interleukin2
cellular immune function
