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移植物中NK细胞数量对HLA全相合同胞造血干细胞移植术后转归的影响 被引量：3

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摘要 近年来的国内外研究显示，异源活化的自然杀伤（NK）细胞能够分离移植物抗白血病（GVL）效应和移植物抗宿主病（GVHD），在发挥强大GVL效应的同时不增加甚至降低GVHD的发生率，降低复发率，改善移植预后。但是，移植物中NK细胞的含量与移植预后的关系目前研究尚少。
作者 彭碧云 唐晓文 吴德沛 孙爱宁 仇惠英 朱子玲 朱明清 常伟荣 沈文红 戴兰 陈黎
机构地区 苏州大学附属第一医院血液科、江苏省血液研究所
出处 《中华血液学杂志》 CAS CSCD 北大核心 2010年第1期57-58,共2页 Chinese Journal of Hematology
基金 江苏省卫生厅“科教兴卫工程”医学重点人才培养基金（RC2007072） 江苏省人事厅“六大人才高峰”资助项目（07-B-019） 苏州市国际科技合作项目（SWH0815） 苏州市科技发展计划项目（YJS0912）
关键词 自然杀伤(NK)细胞 造血干细胞移植 移植物抗宿主病 术后转归 细胞数量 HLA 移植物抗白血病 同胞
分类号 R457.1 [医药卫生—治疗学]
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参考文献10

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同被引文献46

  • 1张鹏,鹿全意,王昭,赵江宁,牛小青,蔡玉璇.环孢素A、甲氨喋呤、霉酚酸酯联合抗胸腺细胞球蛋白预防HLA不全相合移植的移植物抗宿主病[J].福建医科大学学报,2006,40(6):594-596. 被引量：3
  • 2Craddock CF. Full-intensity and reduced-intensity allogeneic stem cell transplantation in AML. Bone Marrow Transplant,2008,41: 415-423.
  • 3Pavletie ZS, Joshi SS, Pirruccello S J, et al. Lymphocyte reconstitution after allogeneic blood stem cell transplantation for hematologic malignancies. Bone Marrow Transplant,1998,21:33- 41.
  • 4Matthews K, Lim Z, Pearce L, et al. Rapid recovery of lymphocyte subsets is not associated with protection from relapse of myelodysplastic syndromes and acute myeloid leukaemia after haematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab. Br J Haematol, 2010,149:879- 889.
  • 5Buhlmann L, Buser AS, Cantoni N, et al. Lymphocyte subset recovery and outcome after T-cell replete allogeneic hematopoietic SCT. Bone Marrow Transplant, 2011,46 : 1357- 1362.
  • 6Burke MJ, Vogel RI, Janardan SK, et al. Early lymphocyte recovery and outcomes after umbilical cord blood transplantation (UCBT) for hematologic malignancies. Biol Blood Marrow Transplant,2011,17:831- 840.
  • 7Lai Y, Ma J, Schwarzenberger P, et al. Combination of CsA, MTX and low-dose, short-course mycophenolate mofetil for GVHD prophylaxis. Bone Marrow Transplant, 2009, 43: 61-67.
  • 8Rowlings PA, Przepiorka D, Klein JP, et al. IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade. Br J Haematol, 1997,97 : 855-864.
  • 9Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant, 2005,11 : 945-956.
  • 10Einsele H, Ehninger G, Steidle M, et al. Lymphocytopenia as an unfavorable prognostic factor in patients with cytomegalovirus infection after bone marrow transplantation. Blood, 1993, 82: 1672-1678.

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中华血液学杂志
2010年 第1期

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