摘要
MicroRNA(miRNA)是一组20～24个核苷酸长度的非编码单链RNA,在转录后水平抑制或诱导靶基因表达。在缺氧缺血性脑损伤(HIBD)中,miRNA通过缺氧诱导因子1α(HIF-1α)依赖或非依赖途径,快速可逆地调控中枢神经系统损伤及修复过程。现就HIF-1α、miRNA功能及HIBD后其相互作用机制作一综述,总结miRNA在HIBD诊断及治疗中发挥的重要作用。
MicroRNA （miRNA） are a class of 20 -24 nucleotide noncoding single -stranded RNAs that regulate target gene expression at post - transcriptional level. Studies on hypoxia - isehemia brain damage （HIBD） had shown that the rapid and reversible roles of miRNA in impairment and repair of central nervous system act on hypoxia induced factor lct（ HIF-1α ） - dependent/independent pathway. In this study, the functions of HIF-1α and miRNA, their interaction mechanisms after HIBD are reviewed, as well as increasingly significant applications of miRNA as diagnostic biomarkers and therapeutic targets with the further research.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2011年第24期1890-1892,共3页
Journal of Applied Clinical Pediatrics
基金
长江学者和创新团队发展计划资助(IRT0935)
