摘要
目的观察环磷酰胺联合多西紫杉醇治疗既往接受过多程化疗的转移性乳腺癌患者的近期疗效和毒副反应。方法 26例接受过多程化疗的转移性乳腺癌患者接受环磷酰胺联合多西紫杉醇方案化疗,环磷酰胺:600 mg/m2,d1;多西紫杉醇37.5 mg/m2,d1,8,21 d为1个周期,3个周期后评价疗效和毒副反应。结果 26例患者总有效率为38.5%(10/26),临床获益率为84.6%(22/26)。主要毒副反应有白细胞减少、脱发、恶心、呕吐、肝功能损害、血小板减少及心脏毒性,毒副反应程度较轻。结论环磷酰胺联合多西紫杉醇方案可作为晚期乳腺癌姑息化疗的又一选择方案。
Objective To investigate the curative efficacy and toxicities of cyclophosphamide combined with docetaxel in the treatment of patients with metastatic breast cancer who previously underwent multi-pass chemotherapy. Methods The 26 patients with metastatic breast cancer who previously underwent multi-pass chemotherapy were treated with chemotherapy：cyclophosphamide 600 mg/m2, dl ;docetaxel 37.5 mg/m2, d1.8 ,21 days were 1 cycle, the efficacy and toxicities were evaluated after 3 cycles of chemotherapy. Results Of all the 26 patients, the response rate was 38.5% （10/26） ,and the clinical benefit response rate was 84.6% （22/26）. The main toxicities were leucopenia,alopecie, nausea, vomiting, hepatic function lesion, thrombocytopenia and cardiotoxicity, all the toxicities were mild. Conclusion Cyclophospha- mide combined with docetaxel can be applied to the palliative chemotherapy for patients with metastatic breast cancer.
出处
《肿瘤基础与临床》
2011年第6期497-498,共2页
journal of basic and clinical oncology
关键词
转移性乳腺癌
姑息化疗
环磷酰胺
多西紫杉醇
metastatic breast cancer
palliative chemotherapy
cyclophosphamide
docetaxel
