期刊文献+

以国产多西紫杉醇为主的化疗方案治疗转移性乳腺癌20例 被引量:1

原文传递
导出
摘要 目的探讨以多西紫杉醇为主治疗转移性乳腺癌的疗效及患者不良反应。方法晚期转移性乳腺癌20例,既往全部使用过蒽环类药物,且大多数应用过紫杉醇、顺铂化疗。再度进展后选择国产多西紫杉醇单药,或联合异环磷酰胺,或联合卡培他滨化疗。21d为1个周期,2个周期后评价疗效,有效者化疗4个周期以上。结果20例中CR1例,PR13例,SD4例,PD2例,总有效率70%(14/20)。不良反应主要为骨髓抑制和脱发,白细胞减少Ⅲ~Ⅳ度,占50%。结论以多西紫杉醇为主的化疗方案治疗转移性乳腺癌疗效较好,不良反应可耐受。
作者 李伟
出处 《肿瘤研究与临床》 CAS 2009年第2期132-134,共3页 Cancer Research and Clinic
  • 相关文献

参考文献4

二级参考文献15

  • 1粟俭.药物诱导的肿瘤细胞凋亡研究进展[J].国外医学(肿瘤学分册),1995,22(1):7-10. 被引量:59
  • 2江泽飞,宋三泰,徐建明,刘晓晴,李彦博,赵平瑜.单用去甲长春花碱治疗复发转移乳癌[J].中华肿瘤杂志,1996,18(3):208-210. 被引量:45
  • 3[4]Ray-Coquard I, Biron P, Bachelot T, et al. Vinorelbine and cisplatin (CICIC regimen) for the treatment of metastatic breast carcinoma after failure of anthracycline-and (or) paclitaxel-containing regimens. Cancer, 1998, 82:134
  • 4Seidman AD, Tiersten A, Hudis C, et al. Phase Ⅱ trial of paclitaxel by 3-hour infusion as initial and salvage chemotherapy for metastatic breast cancer [ J ]. J Clin Oncol, 1995,13 ( 10 ) :2575-2581.
  • 5Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HEB2 [ J ]. N Engl J Med,2001,344( 11 ) :783-792.
  • 6Robert N, Leyland-Jones B, Asmar L, et al. Phase Ⅲ comparative study of trastuzumab and paclitaxel with and without carbeplatin in patients with HER-2/neu positive advanced breast cancer[J]. Breast Cancer Res Treat,2002,76(supple) :37.
  • 7Seidman AD, Fornier MN, Esteva FJ, et al. Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplificanton[ J ]. J Clin Oncol,2001,19 (10) :2587-2595.
  • 8Early Breast Cancer Trialists " Collaborative Group,Polychemotherapy for early breast cancer: an overview of the randomised trials [ J ]. Lancet, 1998,352 (2) :930-934.
  • 9Henderson C, Berry DA, Demetri GD, et al. Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer[ J ]. J Clin Oncol, 2003,21 ( 6 ) :976-983.
  • 10Citron ML, Berry DA, Cirrincione C, et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741[J]. J Clin Oncol,2003,21 (8) :1431-1439.

共引文献156

同被引文献5

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部