摘要
目的:分析河南地区冠心病患者血脂谱特征及载脂蛋白B(ApoB)/载脂蛋白A-I(ApoA-I)比值与颈动脉内膜中层厚度(cIMT)关系。方法:冠脉造影确诊的正常对照组和冠心病患者,进行血脂及载脂蛋白生化分析,B型超声测量cIMT,统计学分析性别分组和ApoB/apoA-I比值分组血脂谱特征和cIMT的差异。多元回归分析cIMT和血脂谱的关系。结果:①以性别分组的冠心病患者中,高密度脂蛋白胆固醇(HDL-C)、ApoA-I、ApoB/apoA-I、低密度脂蛋白胆固醇(LDL-C)/HDL-C、总胆固醇(TC)/HDL-C和cIMT在男女两组有显著差异(均P<0.05)。②以ApoB/apoA-I比值分组(男性截断点0.8,女性截断点0.7)的冠心病患者,年龄和他汀治疗率在ApoB/apoA-I比值低的男女两组均高于比值高的组(均P<0.05),糖尿病、吸烟、饮酒、cIMT和其他血脂谱指标在ApoB/apoA-I比值高的男女两组均高于比值低的组(均P<0.05)。③多元回归分析显示,仅ApoA-I、ApoB和ApoB/apoA-I回归系数有统计学差异(均P<0.05)。结论:冠心病患者cIMT与ApoB/apoA-I比值显著相关。ApoB/apoA-I比值反映cIMT的敏感性比LDL-C更好。
AIM： To study the characteristics of lipid profile and the relationship between ApoB/apoA-I ratio and carotid artery intima-media thickness（cIMT） in patients with coronary heart disease（CHD） in the Henan Region of China in order to provide evidence for risk factor appraisal and efficiency of medical therapy.METHODS： Serum lipid and apolipoprotein of CHD patients confirmed by coronary angiography were biochemically analyzed.B-mode carotid ultrasonography of cIMT was performed in 812 patients.The differences of lipid profile and cIMT in gender-based groups and ApoB/apoA-I ratio-based groups were analyzed statistically.The relationship between cIMT and lipid profile was studied by multiple regression analysis.RESULTS： In gender-based CHD patients,a significant difference was observed in HDL-C,ApoA-I,ApoB/apoA-I,LDL/HDL,TC/HDL and cIMT between groups（all P0.05）.In ApoB/apoA-I ratio-based CHD patients（the cut-off value for males was 0.8 and for females was 0.7）,age and percentages of treatment with statins were higher in low ApoB/apoA-I ratio group than those in high ratio group（P0.05）.However,the percentage of diabetes mellitus,smoking,alcohol consumption,cIMT and other lipid profile indexes were higher in high ApoB/apoA-I ratio group than those in the low ratio group（P0.05）,Multiple regression analysis showed only significant difference in the regression coefficient of ApoA-I,ApoB and ApoB/apoA-I（P0.05）.CONCLUSION： cIMT is significantly correlated with ApoB/apoA-I ratio in CHD patients.ApoB/apoA-I ratio is a more sensitive correlation index with cIMT than LDL-c.
出处
《心脏杂志》
CAS
2011年第6期737-740,共4页
Chinese Heart Journal
