摘要
目的:考察黄芩提取物(SBG)对H_2O_2所致正常人红细胞(RBCs)氧化的保护作用。方法:将RBCs用黄芩提取物SBG预孵育,经H_2O_2处理后对红细胞溶血作用、脂质过氧化(MDA)、ROS及met-Hb含量进行分析。结果:含有指标成分黄芩苷的SBG对H_2O_2致红细胞损伤致氧化应激溶血率、MDA、ROS及met-Hb含量均具有改善作用,不同SBG中黄芩苷含量较低时改善作用相对较弱。讨论:SBG中的黄酮类化合物具有潜在的抗氧化活性,且黄芩提取物可能对人体血液系统氧化应激具有改善作用。
Objective： To investigate the protective effect of extracts from Scutellaria Baicalensis Georgi. （SBG） towards hydrogen peroxide （H2O2 ）-induced oxidation in normal human erythrocytes （RBCs）. Method： RBCs, pretreated with SBG and challenged with H2O2,were analyzed by the studies of hemolysis,lipid peroxidation, reactive oxygen species （ROS） and methemoglobin production. Re- sult： The oxidative indices were all decreased by incubating the RBCs with SBG which contained baicalin, a kind of marker components in SBG, and the effects depended on the concentration of baicalin. Conclusion： The findings demonstrate that the flavones in SBG show potent antioxidant properties which have beneficial effect in oxidative stress in human blood system.
出处
《中国药师》
CAS
2011年第11期1572-1575,共4页
China Pharmacist
关键词
黄芩
抗氧化
红细胞
Radix Scutellariae Baicalensis
Antioxidant
Normal human erythrocytes
