摘要
目的:大鼠心肌缺血后,U50488H激活阿片受体,观察其对心肌缺血大鼠血流动力学及心律失常的影响。方法:建立大鼠心肌缺血再灌注损伤模型,动物随机分为4组,I组:对照组(手术但未实施缺血再灌注及药物干预);Ⅱ组:缺血/再灌注组(I/R);Ⅲ组:I/R+U50488H干预组;Ⅳ组:I/R+U50488H+Nor-BNI共同干预组。试验中监测术前、缺血及再灌注后ECG、心率(HR)、动脉压(ABP)、心输出量(CO)、每搏量(SV)等血流动力学指标;记录各种类型心律失常的发生情况。结果:κ阿片受体激动剂干预组再灌注后ABP、CO和SV降低;心肌缺血前给予阿片受体激动剂,可减少心律失常的发生,应用阿片受体阻断剂Nor BNI后该作用被逆转。结论:阿片受体激动剂U50488H产生了抗大鼠心肌缺血心律失常的作用。
Objective：To monitor the changes of hemodynamics and investigate the effects of U50488H（a opioid receptor）stimulation on myocardial ischemic arrhythmias in rats.Methods：Rats were randomly divided into control,ischemia reperfusion（I/R）,U50488H＋I/R,and Nor-BNI＋U50488H＋I/R groups.Electrocardiogram（ECG）,heart rate（HR）,arterial blood pressure（ABP）,cardiac output（CO）,stroke volume（SV） and the incidence of ventricular arrhythmia were recorded in rats.Results：ABP,CO and SV were decreased,the chance of myocardial ischemic arrhythmias was reduced with the adminstration of U50488H in rats.The effect of U50488H was abolished by Nor-BNI.Conclusion：U50488H has some direct protective effects during myocardial ischemia and reperfusion in rats and the chance of myocardial ischemic arrhythmias is decreased by U50488H.
出处
《广西医科大学学报》
CAS
2011年第5期668-670,共3页
Journal of Guangxi Medical University
基金
广东省卫生厅医学科研课题(No.A2008596)
