摘要
本实验观察了四种阿片受体亚型的激动剂对大鼠腹腔巨噬细胞(Mφ)释放过氧化氢(H_2O_2的影响。吗啡、β-内啡肽和κ受体激动剂NDAP能抑制Mφ释放H_2O_2。纳洛酮能翻转吗啡和β-内啡肽的这一作用,κ受体阻断剂nor-BNI能拮抗NDAP的作用。δ受体激动剂DADLE仅在高浓度时才抑制Mφ释放H_2O_2。以上结果表明,Mφ上可能存在若干类型阿片受体,其中μ、ε和κ受体对Mφ释放H_2O_2具有明显的调节作用。
In order to investigate which type of opioid receptor could regulate the function of mac-rophages (Mφ), we observed the effect of some opioids on the release of hydrogen peroxide (H2O2) from peritoneal Mφ. Morphine and β-endorphin (0.1nmol/L-1μmol/L) as well as NDAP (10nmol/L-1μumol/L) significantly reduced H2O2 release. The inhibitory effect of morphine and β-endorphin could be blocked by naloxone, and that of NDAP by nor-BNI, a specific antagonist for kappa receptors. DADLE, a relatively specific agonist for delta receptors, had only a mild inhibition for H2O2 release at the concentration as high as 1μmol/L. The results suggest that there might be opioid receptors on Mφ similar to CNS and μ, ε,κ receptors could regulate the release of H2O2 from Mφ.
出处
《动物学报》
SCIE
CAS
CSCD
1991年第1期52-57,共6页
ACTA ZOOLOGICA SINICA
关键词
阿片受体
巨噬细胞
过氧化氢
大鼠
Opioid receptors, Macrophages, Hydrogen peroxide.
