摘要
为研究氡及其子体对大鼠肺组织的病理损伤和外周血损伤的生物学效应,以多功能生态氡室对SD大鼠进行氡及其子体染毒,累积染毒剂量分别达60、90、120工作水平月(Working level month,WLM)后,收集外周血,观察外周血中白细胞计数和分类的变化。同时选取右肺及与其相连的支气管,观察大鼠肺及支气管的损伤程度。大鼠吸入氡及其子体后,与对照组相比,外周血粒细胞比例明显增加,淋巴细胞比例显著减少(p<0.05)。肺组织出现肺间质充血水肿,气肿,炎症细胞浸润等病理变化。随着氡及其子体累积暴露剂量增加,各种类型病理变化比例、范围和严重程度增加,肺泡毛细血管内血栓发生率增高。氡及其子体可使外周血粒细胞比例增加,淋巴细胞比例减少;肺及其支气管损伤程度随着氡及其子体累积暴露剂量增加而增加。
To investigate the pathological damage of lung and peripheral blood damage in rats exposed to radon and its progeny, Sprague-Dawley rats were exposed to radon in multifunction ecological radon chamber with the cumulative dose up to 60, 90 and 120 WLM, respectively. The numbers and proportions of white cells in peripheral blood were measured meanwhile the degree of lung and its bronchus injury was observed. It was found that proportions of white blood cells increased in the proportion of granulocytes and decreased in the proportion of lymphocytes （p〈0.05）. A series of pathological alterations were observed including hyperaemia and edema in the alveolus, emphysema, infiltration of inflammatory cells. The occurrence of different pathology, its scope and the serious degree, alveolar capillaries and incidence of thrombosis increased with the accumulation exposure dosage. As a result, radon and its progeny can increase the proportion of granulocytes and decrease the proportion of lymphocytes in peripheral blood cells. At the same time the serious degree of lung and its bronchus injury will increase with the increment of the accumulation exposure dosage.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
2011年第6期365-370,共6页
Journal of Radiation Research and Radiation Processing
基金
二炮后勤科研计划项目(09-09)资助
关键词
氡
大鼠
肺
白细胞
Radon, Rats, Lung, White blood cells
