摘要
目的研究表皮生长因子受体(EGFR)和磷酸肌醇3激酶、丝氨酸/苏氨酸蛋白激酶信号通路相关蛋白在非小细胞肺癌(NSCLC)组织中的表达以及其临床意义。方法应用免疫组化学SP法检测100例NSCLC组织及其相应正常癌旁组织中的EGFR、PI3K、AKT蛋白表达水平。结果 100例正常的癌旁组织中EGFR、PI3K及AKT蛋白的阳性表达率分别为13%、11%、7%,100例NSCLC组织中EGFR、PI3K及AKT蛋白的阳性表达率分别为63%、51%、23%,两种组织的3种阳性表达率差异均有统计学意义(P<0.05)。结论 EGFR可能通过激活其下游的PI3K/AKT通路发挥致癌作用。
Objective To explore the role of epidermal growth factor （EGFR） and phosphotylinosital 3 kinase/serine threonine protein kinase （PI3K/AKT） signal pathway in non-small cell lung cancer（NSCLC）. Methods The immunohistochemical SP method was used to measure the protein expression of EGFR, PI3K and AKT in the 100 cases of NSCLC and normal paracancerous tissues. Results The positive expression rate of EGFR,PI3K and AKT was 13%, 11% and 7% respectively in the normal paracancerous tissues, while the positive expression rate of EG- FR,PI3K and AKT in the NSCLC was 63% ,51% and 23% , which showed significant statistical difference （P 〈 0.05 ）. Conclusion The expression of the EGFR, PI3 K and AKT in NSCLC is higher than those in the normal paracancerous tissues, so EGFR may play a key role in its cancerogenesis by activating the down stream pathway of PI3K/AKT in NSCLC.
出处
《安徽医科大学学报》
CAS
北大核心
2011年第12期1264-1266,共3页
Acta Universitatis Medicinalis Anhui
基金
安徽医科大学中青年学术骨干基金[编号:校人字(2009)38]
