摘要
目的调查分析2010年华北地区医院临床分离细菌分布以及对常用抗菌药物的药敏率。方法以北京、天津、内蒙古及山西的各医院为成员单位,按照统一方案分离菌株,进行药物敏感性试验,结果用WHONET5.5软件进行统计分析。结果 2010年华北地区11所医院共收集细菌20 071株,其中革兰阳性菌6518株占32.5%,革兰阴性菌13 553株占67.5%;MRSA和MRCNS的检出率分别为55.6%和71.4%,未发现万古霉素不敏感的葡萄球菌属;粪肠球菌对万古霉素、替考拉宁不敏感株检出率分别为5.1%、0.2%,屎肠球菌对万古霉素、替考拉宁不敏感菌株分别为5.5%、1.8%;大肠埃希菌、肺炎克雷伯菌、产酸克雷伯菌及奇异变形菌产ESBLs检出率分别为58.1%、32.0%、30.1%及21.3%;肺炎链球菌201株,其中耐青霉素肺炎链球菌占5.4%;流感嗜血菌132株,产酶率为14.8%;肠杆菌科细菌仍对亚胺培南和美罗培南保持>93.0%的敏感率。结论细菌耐药性仍呈上升趋势,需要关注耐万古霉素肠球菌、耐碳青霉烯类肠杆菌科细菌及多药耐药非发酵菌,采取积极措施控制进一步恶化。
OBJECTIVE To investigate bacterial distribution and antimicrobial resistance in north China in 2010. METHODS Bacterial susceptibility testing was carried out according to an agreed protocol and standard.The results were analyzed by WHONET 5.5. RESULTS A total of 20 071 clinical isolates were collected from Jan to Dec 2010,of which Gram-negative strains and Gram-positive strains accounted for 67.5% and 32.5%,respectively.The incidence of MRSA and MRCNS were 55.6%and 71.4%respectively.There were 5.1% and 0.2% of E.faecalis and 5.5%and 1.8%of E.faecium strains resistant to vancomycin and teicoplanin,respectively.58.1% of E.coli,32.0% of Klebsiella pneumonia,30.1% of Klebsiella oxytoca and 21.3%of P.mirabilis were ESBLs-positive strains.Isolates of Enterobacteriaceae were still highly sensitive to imipenem and meropenem,the average susceptibility was more than 93.0%.However,up to 29.0%,22.8% of Pseudomonas aeruginosa strains were resistant to the two carbapenems.In the 201 strains of S.pneumoniae,5.4% were identified as PRSP.β-lactamase were detected in 14.8% of Hemophylus influenzae isolates. CONCLUSIONS Bacterial resistance is still on the rise in the area.Vancomycin-resistant Enterococci,carbapenems-resistant Enterobacteriaceae and multidrug-resistant non-fermenters are getting common,which need effective measures to contain further deterioration.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第23期4909-4914,共6页
Chinese Journal of Nosocomiology
关键词
华北
细菌耐药性
革兰阴性菌
革兰阳性菌
North China
Bacterial resistance
Gram-negative bacteria
Gram-positive bacteria
