摘要
目的:探讨高氧液对急性脑梗塞患者的临床疗效和抗氧化损伤的作用。方法:将58例急性脑梗塞病人随机分为高氧液治疗组和常规治疗对照组,两组分别在治疗前和治疗后24h、48h抽取静脉血5mL,采用比色发检测各组各时间点血浆的超氧化物岐化酶(SOD)、丙二醛(MDA)和一氧化氮(NO)含量,同时通过NDS评定治疗期内两组的临床疗效。结果:高氧液治疗组治疗后血浆SOD含量上升,MDA、NO含量下降,与对照组比较有显著性差异(P<0.05),同时NDS评分显示高氧液治疗组NDS得分低于对照组(P<0.05)。结论:高氧液可能通过清除氧自由基、抗脂质过氧化损伤减轻急性脑梗塞缺血再灌注损伤。
Objective： To study the anti-oxidative damage effect of hyperoxia solution on patients with acute cerebral infarction.Method： 58 patients with acute cerebral infarction were randomly divided into hyperoxia solution therapy group and normal therapy control group.Each group was drawn blood and the SOD,MDA and NO concentration of blood plasma was measured according to the kit protocol before and 24h,48h after therapy.Meanwhile the clinical curative effect during the therapy was evaluated by the NDS standard.Result： The SOD concentration of blood plasma in hyperoxia solution therapy group remarkably rised and the MDA,NO concentration of blood plasma remarkably decreased after therapy.There was significant difference between the two group（P 0.05） in the concentration contrast of SOD,MDA,and NO during the therapy.The NSD score in hyperoxia solution therapy group was lower than the control group（P 0.05）.Conclusion： Hyperoxia solution may relieve ischemical reperfusion injury in acute cerebral infarction by means of eliminating oxygen free radical and anti-oxidative damage.
出处
《河北医学》
CAS
2011年第12期1570-1573,共4页
Hebei Medicine
关键词
高氧液
急性脑梗塞
抗氧化损伤
Hyperoxia solution
Acute cerebral infarction
Anti-oxidative damage
