摘要
目的 观察高氧液（HO）对失血性休克家兔血气和血液流变学的影响,评价其用于休克早期救治的价值。方法 以林格氏液（RS）为基液制备HO。22只家兔随机分为两组:林格氏液组RS组）和高氧液组（HO组）,每组11只。制备失血性休克模型,经股动脉在5min内放血,放血量占全身血量的45％。60min后分别静脉输注10ml/kg RS或HO。记录平均动脉压（MAP）和输液后动物4h存活率。分别于休克前、休克60min、输液后30min、60min取动脉血测定血气和血液流变学指标。结果 休克后MAP明显下降,全血高切变率表观粘度（BV）、血浆粘度（PV）,红细胞聚集指数（AI）明显升高;与RS比较,HO能迅速提高MAP,提高SaO2和PaO2,降低BV、PV、AI（P<0.05）,动物4h存活率明显提高。结论 HO对出血性休克早期救治具有较高的实用价值。
ve To investigate the effects of hyperoxygenated solution (HO) on blood gas and hemorrheology during hemorrhagic shock in rabbits and evaluate its therapeutic efficacy. Methods Twenty-two male rabbits weighing (2.10±0.26) kg were randomly divided into two groups of 11 each: Ringer's solution group (RS) and hyperoxygenated solution group (HO) . Anesthesia was induced with 3 % pentobarbital 40 mg·kg-1. Left femoral artery was cannulated with a Y-tube for MAP monitoring and blood-letting. After the animal was stabilized for 20 min, 45% of blood volume was shed in 5 min. 60 min later RS or HO 10 ml·kg-1 was infused intravenously. Blood gas was analyzed and hemorrheology was measured before and 60 min after shock was established and 30, 60 min after fluid infusion. MAP and 4h-survival rate after infusion were recorded.Results (1) MAP was reduced from (12.6±0.85)kPa to (5.72±1.02)kPa during shock. After infusion MAP increased significantly, there was no significant difference between the two groups at 5, 10 and 30 min but at 60 min after infusion MAP in HO group was significantly higher than that in RS group (P< 0.05) . (2) After the animals were in shock for 60 min there was no significant change in SaO2, PaO2 but pH and BE decreased significantly indicating metabolic acidosis. SaO2, PaO2 and BE were significantly higher in HO group than those in RS group at 30 and 60 min after infusion. pH was significantly higher in HO group than that in RS group only at 30 min after infusion. (3) Absolute blood viscosity (BV), plasma viscosity (PV) and erythrocyte aggregation index (AI) increased significantly during shock and decreased after infusion. 60 min after infusion BV, PV and AI were significantly lower in HO group than those in RS group. (4) 4h-survival rate was 18.2% in RS group and 54.5% in HO group.Conclusions HO is more effective in the early stage of hemorrhagic shock.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2002年第4期228-230,共3页
Chinese Journal of Anesthesiology
基金
长江学者特配骨干教师基金资助项目
陕西省自然科学基金资助课题(99SM39)
