摘要
目的研究3种不同处方的痰热清口服液抗流感病毒鼠肺适应株及抗菌作用,并比较三者作用的强弱。方法以病毒滴鼻感染小鼠、采用体内、外抗菌试验观察痰热清口服液的作用。结果三者均可使病毒感染小鼠死亡率明显降低,存活时间明显延长,含熊去氧胆酸或熊胆粉提取物的痰热清口服液能明显降低肺指数,不含熊去氧胆酸和熊胆粉提取物的口服液此作用稍弱,三者对肺病变分级的影响差别无显著性意义;三者均能降低金黄色葡萄球菌、乙型溶血性链球菌感染小鼠的死亡率,体外对上呼吸道感染细菌有一定的抑菌和杀菌活性,含熊去氧胆酸的痰热清口服液作用优于含熊胆粉提取物、不含熊去氧胆酸和熊胆粉提取物的口服液。结论 3种处方的痰热清口服液均有抗流感病毒和抗菌的作用,其中不含熊胆粉提取物和熊去氧胆酸的口服液作用较弱,含熊去氧胆酸口服液的抗病毒作用与含熊胆粉提取物的无明显差异,抗菌作用优于后者。
OBJECTIVE To study and compare of the effects of the three different recipes of Tanreqing oral liquid on influenza virus FM1 and antibacterial activity.METHODS The mice were infected with influenza virus from nose.The antibacterial experiments in vivo and in vitro were carried out respectively.RESULTS All of them could decrease the death rate of virus infected mice and prolong the survival time obviously.Tanreqing oral liquid containing ursodeoxycholic acid or bear gall powder could reduce the lung index obviously and it had less activity if there were none of them.The effects of the three oral liquid on the grade of the lung pathological changes were not significant vs model group.They also could decrease the death rate of mice infected with staphylococcus aureus or beta-hemolytic streptococci and had bacteriostasis and batericidal activity in vitro.The oral liquid containing ursodeoxycholic acid was the best.CONCLUSION They could provide protection from influenza virus and bacterium.The antiviral activity of Tanreqing oral liquid containing ursodeoxycholic acid was the same as which containing bear gall powder.And the antibacterial activity of the former one was better than the latter one.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2011年第6期553-556,共4页
West China Journal of Pharmaceutical Sciences
