摘要
目的：探讨肺泡巨噬细胞在纤维性间质性肺病胶原纤维异常沉积中的作用。方法：应用ＨＥ 染色、Ｍａｓｓｏｎ 三色染色和免疫组织化学染色。结果：在纤维性间质性肺病组和疾病对照组之间，肺泡巨噬细胞ＴＧＦβ１ 和ｂＦＧＦ阳性表达率差异均有显著性（ Ｐ＜ ０－０５） ；肺泡巨噬细胞ＰＤＧＦα受体阳性率差异亦有显著性（Ｐ＜０－０５）。在增生性肺泡Ⅱ型上皮细胞，ＰＤＧＦα受体阳性表达率，无胶原沉积组高于胶原沉积组（ Ｐ＜ ０－０５） ；而ＴＧＦβ１ 阳性表达率胶原沉积组高于无胶原沉积组（ Ｐ＝ ０－０１）。结论：肺泡巨噬细胞参与了纤维性间质性肺病及其胶原纤维异常沉积的发生发展过程。
Purpose To study the role of pulmonary macrophages in the collagen deposition of fibrotic interstital lung disease (FILD). Methods HE staining, Massons trichrome staining and immunohistochemistry. Results It was demonstrated that the positivity rates of TGF β 1, bFGF and PDGF α receptors in the pulmonary macrophages of FILD cases were significantly higher than those of disease control cases( P <0 05). Conclusion Pulmonary macrophages could play a part in the process of abnormal collagen deposition in FILD.
出处
《临床与实验病理学杂志》
CAS
CSCD
1999年第5期420-422,I063,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
肺纤维化
免疫组织化学
巨噬细胞
肺泡
pulmonary fibrosis
immunohistochemistry
macrophages, alveolar
