摘要
光学活性芳族氰醇以及由它转变而成的α-羟基酸、α-羟基酯、α-羟基酮和β-羟基胺等光学活性异构体都是重要的农药和医药中间休,从实用观点看,利用催化不对称合成来制取光活性氰醇,更具有重要意义。近年来,环状二肽Cyclo[L(D)-Phe-L(D)-His]用于催化芳族氰醇的不对称合成,由于具有与D-羟腈酶相类似的高活性和高对映选择性。
Twenty chiral catalysts,among which twelve were prepared or purified in thiswork, have been used in the asymmetric synthesis of cyanohydrins from benzaldehyde. Theactivity and enantioselectivity of these catalysts in the reaction have been observed. The Op-tical yields of these asymmetric reaction varied from zero to about 60%. The investigationon the stability of the cyanohydrins showed that the purified cyanohydrins could be opti-cally stable within a week without apparent decrease of their optical rotation and chemi-cally stable over 5 months. The mechanism of the reaction and the evaluation of enantio-selectivity of the catalysts have also been discussed.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1990年第5期464-470,共7页
Chinese Journal of Organic Chemistry
基金
中国科学院院内基金
关键词
光活性氰酸
不对称合成
稳定性
asymmetric synthesis
optically active eatalyst
optically active cyanohydrin
stability
