期刊文献+

浅低温对肺癌根治术患者Th1/Th2型细胞因子的影响 被引量:10

原文传递
导出
摘要 恶性肿瘤患者术前存在着不同程度的免疫功能抑制,手术、麻醉和低体温等又可进一步加重免疫功能的抑制,使术后感染和肿瘤复发、转移的概率增加。手术过程中由于麻醉、环境温度、体腔暴露等因素导致患者核心温度降低,处于浅低温状态[1]。浅低温可诱导IL-2、IL-10等细胞因子的表达发生变化[2],该作用可能与其抑制免疫功能有关。机体抗肿瘤免疫主要是细胞免疫,Th1/Th2型细胞因子是细胞免疫应答调节中的关键环节。本研究拟探讨浅低温对肺癌根治术患者Th1/Th2型细胞因子的影响,进一步研究浅低温对恶性肿瘤患者细胞免疫功能的影响。
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 2011年第9期1151-1152,共2页 Chinese Journal of Anesthesiology
  • 相关文献

参考文献6

  • 1Forst RM.The etiology and management of inadvertent perioperative hypothermia.J Clin Anesth,1995,7(8):657-674.
  • 2张倩,丁素春,金玄玉.围手术期轻度低温对颅脑手术患者血浆IL-2及IL-10的影响[J].中国血液流变学杂志,2006,16(1):64-66. 被引量:5
  • 3王德生,张守信.亚低温与脑保护.北京:科学出版社,2002:82.
  • 4潘建平,邵传森.医学免疫学.杭州:浙江大学出版社,200680-99.
  • 5Ide H,Kakinchi T,Furuta N,et al.The effect of cardiopulmonary bypass on T cells and their subpopulations.Ann Thorac surg,1987,44(3):277-282.
  • 6Yu J,Ren X,Cao S,et al.Thl polarization and apoptosis-inducing activity of CD4 + T-cells in cytokine-induced killers might favor the antitumor cytotoxicity of cytokine-induced killers in vivo.Cancer Biother Radiopharm,2006,21(3):276-284.

二级参考文献8

  • 1Ikeda T,Sessler DI,Marder D,et al.Influence of hermoregulatory vasomotion and ambient temperature variation on the accuracy of core temperatures,timates by cutaneous liquid crystal the mometers[J].Anesthesiology,1997,86(3):603~612.
  • 2Forst RM.The etiology and management of inadvertent perioperative hypothermia[J].J Clin Anesth,1995,7:657~674.
  • 3Kurz A,Sessler DI,Lenhardt R.Perioperative normothermia to reduce the incidence of surgical wound infection and shorten hospitalization[J].N Engl J Med,1996,334:1209~1215.
  • 4Atkins MB.Interleukin-2:clinical applications[J].Semin Oncol,2002,29:12~17.
  • 5Russwurm S,Stonans I,et al.Direct influence of mild hypothermia on cytokine expression and release in cultures of human peripheral blood mononuclear cells[J].J Interferon Cytokine Res,2002,22(2):215~221.
  • 6Beilin B,Shavit Y,Razumovsky J,et al.Effects of mild perioperative hypothermia on cellular immune responses[J].Anesthesiology,1998,89:1134~1140.
  • 7Mack VE,McCarter MD,Naama HA,et al.Dominance of Thelper 2-type cytokines after severe injury[J].Arch Surg,1995,131:1303~1305.
  • 8Lee SL,Battistella FD,Go K.Hypothermia induces T-cell production of immunosuppressive cytokines[J].J Surg Res,2001,100(2):150~153.

共引文献5

同被引文献106

引证文献10

二级引证文献64

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部