心理干预联合硬膜外分娩镇痛对产妇IL-2、IL-6、TNF-α的影响被引量：1

Effect of Psychological Intervention Combined with Epidural Labor Analgesia on Serum IL-2, IL-6 and TNF-α in Parturients

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摘要 [目的]探讨心理干预联合硬膜外分娩镇痛对产妇血清白介素-2（IL-2）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）的影响.[方法] 选择160 例无相关禁忌的初产妇,ASAⅠ～Ⅱ级,随机分成两组,每组80例,R组为硬膜外分娩镇痛,P组为硬膜外分娩镇痛联合心理干预（呼吸训练法和渐进性肌肉放松法）,比较两组VAS评分、血浆IL-2、IL-6、TNF-α水平.[结果] 镇痛效果（VAS评分）P组明显低于R组 P组产妇胎儿娩出时（T3）、产后24h（T4）与R组比较,IL-6、TNF-α水平有明显的降低,IL-2水平明显升高,差异具有显著性（P〈0.05）.[结论] 心理干预联合硬膜外分娩镇更有效的减轻产时疼痛强度,降低炎性反应,减轻产后免疫功能抑制. [Objective]To explore the effect of psychological intervention combined with epidural labor analgesia on serum interteukin-2（IL-2）, interleukin 6（IL-6） and tumor necrosis factor-alpha（TNF-α） in parturients. [Methods]Totally 160 ASAⅠ～Ⅱ primiparas without relative labor taboos were randomly divided into two groups with 80 cases in each. Group R received epidural labor analgesia. Group P received epidural labor analgesia and psychological intervention（breathing training and progressive muscle relaxing）. The VAS score, plasma IL-2, IL-6 and TNF-α were compared between two groups. [Results] VAS score in group P was significantly lower than that in group R. Compared with group R at fetal disengagement（T3 ） and after delivery （T4）, serum level of IL-6 and TNF-α in group P significantly decreased, and IL-2 obviously increased. There was significant difference between two groups（ P 〈0.05）. [Conclusion] Psychological intervention combined with epidural labor analgesia can more effectively alleviate the pain at delivery, and decrease the inflammatory response, and reduce the inhibition of immune function.

作者潘麒陈安基孙立红

机构地区湖南省常德市妇幼保健院常德市第一人民医院麻醉科

出处《医学临床研究》 CAS 2011年第2期298-300,共3页 Journal of Clinical Research

关键词镇痛产科镇痛硬膜外白细胞介素2 白细胞介素6 肿瘤坏死因子 analgesia, obstretrical analgesia, epidural interleukin-2 interleukin 6 tumor necrosis factor

分类号 R719 [医药卫生—妇产科学]

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