摘要
树突状细胞是目前已知最有效的专职抗原提呈细胞，能诱导针对肿瘤的特异性细胞毒性T淋巴细胞反应，在抗肿瘤免疫中发挥着重要作用。运用树突状细胞的这一特性制备的肿瘤疫苗在体外和体内实验都已证明其抗肿瘤效应。近年来，基因修饰的树突状细胞疫苗由于其更出色的抗肿瘤效应成为研究的热点。本文就目前基因修饰的树突状细胞疫苗的研究现状，包括转染方法、目的基因及临床研究进展做一综述。
Dendritic cells（DCs） are the most potent antigen presenting cells, which play a vital role in the initiation of immune response by presenting antigens to T cells and followed by induction of T-cell response. This established function of dendritic ceils has attracted much attention in efforts to develop useful vaccines for the treatment of cancer. In several studies, DCs were genetically engineered by tumorassociated antigens or by immune molecules such as costimulatory molecules, cytokines, and chemokines. These new DC vaccines are more powerful in stimulating anti-tumor immunity. This review focuses on DC gene modifications for enhancing the multiple effector functions of DC, a variety of transferred genes, and recent clinical trials.
出处
《国际外科学杂志》
2011年第11期767-770,共4页
International Journal of Surgery
关键词
树突细胞
基因治疗
免疫治疗
Dendritic ceils
Gene therapy
Immunotherapy
