摘要
采用微波辐照雄性清洁级Wistar大鼠,观察其对大鼠外周血淋巴细胞亚群的影响。实验结果显示:与对照组相比,10 mW/cm2组、30 mW/cm2组照射后第7天,5 mW/cm2组1、0 mW/cm2组3、0 mW/cm2组照射后第14天,CD3+降低显著;10 mW/cm2组照射后第14天,CD4+降低显著。各辐照组照射后第1、7、14天,CD8+均降低,其中,30 mW/cm2组降低显著;5 mW/cm2组照射后第1天,5 mW/cm2组、30 mW/cm2组照射后第14天,CD4+/CD8+比值降低显著。与T淋巴细胞变化趋势相反,与对照组相比,微波辐照后,各剂量照射组B淋巴细胞CD45RA+均升高,其中,30 mW/cm2照射后第1天,30 mW/cm2组6、0 mW/cm2组照射后第14天,升高显著,并且在照射后第14天,CD45RA+随照射剂量的升高而升高。结果提示,一定剂量的微波辐照能诱发大鼠外周血淋巴细胞亚群比例的改变,导致免疫功能受损。
CD3 ＋ cells in 10 - 30 mW/cm2 groups at 7 d and in 5 - 30 mW/cmz groups at 14 d and CD4＋ T subset in 10 roW/cm2 group at 14 d post radiation were all decreased signifieantiy as compared with control groups. 1 to 14 d after radiation, CD8＋ T cells in all irradiated groups showed reduction, however, only that in 30 mW/cm2 group reduced statistically when compared with control group. CIM＋/CD8＋ ratios in 5 mW/cm2 group at ld and in 5 - 30 mW/cm2 groups at 14 d post radiation were all diminished statistically as compared with control groups. After microwave exposure, CIM5RA＋ B cells showed opposite change to the T cells, for instance, CD45RA＋ B cells in 30 mW/emz group at 1 d and in 30 - 60 mW/cm2 groups at 14 d post radiation increased significantly, which showed better dose-effect relationship 14 d after irradiation.
出处
《辐射防护通讯》
2011年第4期19-22,共4页
Radiation Protection Bulletin
基金
国家自然科学基金(39000386)
毫米波国家重点实验室开放课题(K200909)
军队医药卫生"十一五"基金(09MA026)
关键词
微波
淋巴细胞
大鼠
Microwave Rat Lymphocyte subpopulations
