摘要
生物可降解骨支架设计一直是组织工程的重点,为满足骨支架植入后的性能要求,生物力学特性是其设计过程中首要考虑的问题之一。通过对不同孔隙率骨支架的分析,提出骨支架有效弹性模量与孔隙率和材料弹性模量之间的关系式,作为骨支架设计中的参考。分析中所用骨支架的孔隙率通过组合可控微单元体进行调整,对大量的骨支架的有限元分析表明:0.5%总体压应变下有效弹性模量与孔隙率和弹性模量之间关系是线性的以及对于不同属性材料,其弹性模量越高,随着孔隙率的增大,其有效弹性模量减小速度越快。
Design of biodegradable bone scaffold has been the focus of tissue engineering.In order to meet the performance requirements after implantation,biomechanical property is considered first to be one of the most important factors in the process of scaffold design.According to analysis of different porosity of bone scaffold,relationship between effective elastic modulus porosity and elastic modulus of materials are presented which shall be the reference in scaffold design.Porosity of bone scaffold is adjusted by assembling controllable micro unit in analyzing process.Finite element analysis for large numbers of bone scaffold shows that effective elastic modulus is linear with porosity and elastic modulus in the 0.5% of overall compressive strain.The higher elastic modulus is,the effective elastic modulus decreases faster with increasing porosity for different materials.
出处
《机械设计与制造》
北大核心
2011年第8期57-59,共3页
Machinery Design & Manufacture
基金
国家自然科学基金<缺损骨修复支架的设计理论及方法研究>(60703029)
关键词
骨支架
有效弹性模量
孔隙率
材料弹性模量
可控微单元体
有限元分析
Bone scaffold
Effective elastic modulus
Porosity
Elastic modulus of materials
Controllable micro unit
Finite element analysis
