摘要
目的:调查泛耐药鲍氏不动杆菌喹诺酮类耐药相关基因的存在情况。方法:收集2008年1月-2008年12月住院患者标本中分离的泛耐药鲍氏不动杆菌共20株,采用聚合酶链反应(PCR)的方法分析6种喹诺酮类耐药相关基因。结果:20株泛耐药鲍氏不动杆菌均存在gyrA基因第83位TCA→TTA突变,其它5种基因均未检出。结论:本组20株泛耐药鲍氏不动杆菌耐喹诺酮类药物与gyrA突变和AdeABC外排泵相关。
Objective：To investigate the distribution of resistance-related genes to quinolones in pandrug-resistant Acinetobacter baumannii（A.baumannii）.Methods： From January 2008 to December 2008,20 strains of pandrug-resistant A.baumannii isolated from inpatients were collected from a hospital in China.Then,6 kinds of resistance-related genes to quinolones were analyzed by PCR.Results： All 20 strains（100.0%） performed mutations at 83rd coden in gyrA： TCA→TTA.But other 5 kinds of genes were not detected.Conclusion： Mutations of gyrA and drug efflux pump AdeABC might play a role in resistance to quinolones in these 20 strains of pandrug-resistant A.baumannii.
出处
《中国卫生检验杂志》
CAS
2011年第11期2788-2789,2792,共3页
Chinese Journal of Health Laboratory Technology
关键词
鲍氏不动杆菌
喹诺酮类
GYRA
突变
泛耐药
Acinetobacter baumannii
Quinolones
gyrA
Mutation
Pandrug-resistance
