摘要
目的:研究甲状腺疾病患者血清中抗甲状腺球蛋白抗体(TgAb)和抗甲状腺过氧化物酶抗体(TPOAb)的临床意义。方法:采用全自动化学发光免疫分析法(CLIA)检测230例甲状腺疾病患者和50例健康对照者血清中TgAb和TPO-Ab表达水平,并分析其表达差异。结果:Graves病组的TgAb水平、桥本氏病组的TPOAb水平分别高于其它各组(P<0.05)。Graves病组、桥本氏病组、甲亢病组的TgAb和TPOAb水平明显高于对照组(P<0.01)。自身免疫性甲状腺疾病(AITD)组TgAb和TPOAb水平高于非自身免疫性甲状腺疾病组(P<0.01)。结论:检测血清TgAb和TPOAb水平在诊断各种甲状腺疾病中具有重要的临床意义。
Objective：To evaluate the clinical significance of thyroglobulin antibodies（TgAb） and thyroid peroxidase antibodies（TPOAb） in thyroid diseases.Methods： Serum levels of TgAb and TPOAb were assayed using chemiluminescence immunoassay in 230 thyroid disease patients and 50 healthy controls.Then the differences of the two antibodies were analyzed.Results： Compared with other groups,the higest level of serum TgAb was observed in patients with Graves disease and the higest level of serum TPOAb was observed in patients with Hashimoto′s disease（P0.05）.The levels of serum TgAb and TPOAb in patients with Graves disease,Hashimoto′s disease and hyperthyroidism were higher than those in the control groups（P0.01）.The levels of serum TgAb and TPOAb in patients with Autoimmune Thyroid Disease（AITD） were higher than those in patients with the non-autoimmune thyroid diseases（P0.01）.Conclusion： The detection of serum TgAb and TPOAb is clinically useful in diagnosis of thyroid diseases.
出处
《中国卫生检验杂志》
CAS
2011年第11期2717-2719,共3页
Chinese Journal of Health Laboratory Technology
