摘要
用单核/巨噬细胞（Mo/Mφ）特异性单克隆抗体Ki-M8和抗T细胞活化抗原TLiSAl、Tac单抗对37例自身免疫性甲状腺疾病（AITD）作免疫细胞化学研究。结果表明:无论是桥本甲状腺炎还是Graves病或甲亢合并甲状腺炎,甲状腺组织中均有一定数目Mφ浸润和活化T细胞聚集;甲状腺单个核细胞中Mφ所占比例与活化抗原阳性细胞所占比例呈正相关。认为在AITD甲状腺中Mφ浸润能促进其邻近部位T细胞活化和增殖。
In thirty seven patients with autoimmune thyroid disease (AITD) intrathyroidal macrophages (M ) and activated T cells were identified by alkaline phosphatase anti-alkaline phosphatase (APAAP) immunocytochemical technique using monoclonal antibodies Ki-M8, TLiSA 1 and anti-Tac. Different degrees of infiltration of M (Ki-M8-) and activation of T cells (TLiSA1- or Tac-) were seen in the thyroid tissue of Hashimoto thyroiditis (HT), Graves disease (GD) and Graves disease with thyroiditis(GDAT). However, there were no significant difference in proportions of the positive staining reactions among the different diseases. Staining of serial sections revealed a significant correlation between the proportions of Me and activated T cells in thyroid gland mononuclear cells (TG-MNC). It suggests that infiltration of M may have an influence on intrathyroidal T cell activation in AITD.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1996年第1期17-19,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
甲状腺疾病
自身免疫
巨噬细胞
T细胞活化
Thyroid disease,autoimmune Macrophage T cell activation Immunocytochemistry
