摘要
目的探讨丙型肝炎病毒(HCV)感染与代谢综合征(MS)的临床相关性及其与肝纤维化的关系。方法用荧光定量逆转录聚合酶反应检测样本的HCV-RNA含量;采用ELISA法检测抗-HCV,用全自动生化检测仪测定空腹血糖、甘油三酯(TG)、高密度脂蛋白(HDL-C)、谷丙转氨酶(ALT)、谷草转氨酶(AST)水平。使用全自动血细胞分析仪进行血小板计数。结果 109例HCV感染患者中,有38例高血压,51例高血糖,43例血脂紊乱,33例合并代谢综合征,与对照组相比,有显著性差异。HCV感染合并代谢综合征患者33例中,AST/ALT≥1者有13例,APRI>1.5者有15例,与HCV感染未合并代谢综合征组相比,差异有统计学意义。结论丙型肝炎病毒感染与高血糖、高血压及高血脂、代谢综合征密切相关;代谢综合征可加重丙型肝炎患者的炎症程度,可能是丙型肝炎病毒感染患者肝纤维化的促进因素。
Objective To investigate the clinical relevance and pathogenesis between the hepatitis C virus（HCV） infection and the metabolic syndrome（MS）,and the relationship with liver fibrosis.Methods Fluorescence quantification PCR technology were used to detect HCV-RNA,and anti-HCV with ELISA,and fasting glucose,triglycerides（TG）,high density lipoprotein（HDL-C）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST） levels with Automatic Biochemical Detector,platelet count with automated hematology analyzer.Results 109 cases of patients with HCV infection,there are 51 cases of high glucose,38 cases of hypertension,43 cases of dyslipidemia,33 patients with metabolic syndrome.There are significant differences compared with the control group.HCV infection with metabolic syndrome in 33 cases of patients,AST/ALT≥1 has 13 cases,APRI〉1.5 has 15 cases,compared with the group of HCV infection but non-metabolic syndrome,the difference was statistically significant.Conclusion The relationship between hepatitis C virus infection and high glucose,high blood pressure and high blood lipids,metabolic syndrome is closely;metabolic syndrome in patients with hepatitis C may increase the degree of inflammation,may be a promoting factor from hepatitis C to fibrosis.
出处
《中国实验诊断学》
北大核心
2011年第11期1866-1868,共3页
Chinese Journal of Laboratory Diagnosis
关键词
丙型肝炎病毒
代谢综合征
肝炎
肝纤维化
hepatitis C virus
metabolic syndrome
chronic hepatitis C
Liver fibrosis
