摘要
目的探讨血清人绒毛膜促性腺激素β亚基(β-HCG)、孕酮(P)、糖类抗原125(CA125)、肌酸激酶(CK)及CK/P值在异位妊娠早期诊断中的应用价值。方法选择临床可疑异位妊娠患者72例作为观察组,正常宫内妊娠72例作为对照组。于治疗前采用化学发光免疫分析法测定血清β-HCG、P及CA125水平,采用酶动力学方法检测CK水平,在血清β-HCG基础上分析多项指标联合检测对早期异位妊娠的诊断价值。结果观察组血清β-HCG、P及CA125水平均显著低于对照组(P<0.01);观察组的CK较对照组略有升高,但差别无统计学意义(P>0.05);观察组的血清CK/P值显著高于对照组(P<0.01)。血清β-HCG、P、CA125及CK/P值4项指标联合检测可将诊断特异度、准确性分别提高至88.9%、91.7%。结论血清β-HCG、P、CA125及CK/P值联合检测可提高异位妊娠的诊断率,成为具有临床应用价值的早期诊断异位妊娠的指标。
Objective To explore the value of serum β-human chorionic gonadotropin（β-HCG）,progesterone（P）,carbohydrate antigen 125（CA125）,creatinekinase（CK） and creatinekinase/progesterone（CK/P） for early diagnosis of ectopic pregnancy（EP）.Methods Serum contents of β-HCG,P,CA125（with chemiluminescent immunoassay） and CK（with enzymatic kinetic method） were determined in 72 patients with suspected early ectopic pregnancy（observation group） and 72 normal pregnant women（control group） as to analyze the value of serum β-HCG combined with P,CA125,CK and CK/P for early diagnosis of EP.Results The serum levels of β-HCG,P,CA125 in the observation group were significantly lower than those in the control group（P0.01）;the serum CK level in the observation group was higher than that in the control group,but the difference was not significant（P0.05）;the serum level of CK/P in the observation group was significantly higher than that in the control group（P0.01）.The specificity and accuracy of serum β-HCG combined with P,CA125,CK/P for early diagnosis of EP were respectively 88.9% and 91.7%.Conclusion Combined determination of β-HCG,P,CA125 and CK/P may contribute to the early diagnosis of EP and help to provide a valuable clinical diagnosis.
出处
《新乡医学院学报》
CAS
2011年第6期754-756,共3页
Journal of Xinxiang Medical University
