摘要
随着显微成像技术、数据分析软件及染色技术等的飞速发展,高内涵筛选已成为能够以细胞为研究对象,单次检测获取多靶点数据的检测系统,目前正逐渐被应用到细胞生物学多个领域,并将在未来的药物研发中发挥重要作用。介绍高内涵筛选的3个技术基础,概述目前该技术在药学研究中的应用情况,并对其发展前景及应用中存在的问题进行了讨论。
Along with the evolution of microscopy imaging,data analysis software and staining techniques,high-content screening method has become a highly developed approach to obtain richly descriptive quantitative data of cells using automated microscopy.From early use in drug screening,the technique has been evolved to embrace a diverse range of cell biology,thus playing an important role in the drug research and development in the future.The development of three foundations of high-content screening has been introduced,its recent application in biomedical research and drug discovery has been summarized,and the prospects and problems of the technique have been discussed as well.
出处
《药学进展》
CAS
2011年第11期481-486,共6页
Progress in Pharmaceutical Sciences
基金
国家十一五重大专项基金(No.2009ZX09302-002)
