摘要
目的:观察非洛地平、美托洛尔、硝苯地平对轻、中度原发性高血压患者的治疗效果。方法:选取原发性轻、中度高血压患者95例,按用药方案分成非洛地平组(30例)、美托洛尔组(32例)、硝苯地平组(33例),3组均治疗6周,比较治疗后的血压下降水平和对靶器官保护作用,评价不良反应的发生率。结果:非洛地平组、美托洛尔组、硝苯地平组总有效率分别为90.0%、87.5%、81.8%,非洛地平和美托洛尔的降压效果均优于硝苯地平(P<0.05),不良反应发生率分别为10.0%、12.5%、15.2%;3组的平均心率均有一定程度降低,非洛地平组降低最明显(P<0.05),肌酐清除率均明显增加(P<0.05),左室心肌重量指数明显减少(P<0.05)。结论:非洛地平、美托洛尔是治疗轻、中度原发性高血压较为理想的药物。
OBJECTIVE：To observe the therapeutic effect of felodipine,metoprolol and nifedipine in the treatment of mild to moderate essential hypertension.METHODS：95 patients with mild to moderate essential hypertension were divided into felodipine group（30 cases）,metoprolol group（32 cases）and nifedipine group（33 cases）.They received treatment for 6 weeks.The decrease of blood pressure and protection on target organs were compared after treatment,and the incidence of ADR were evaluated.RESULTS：Total effective rates of felodipine group,metoprolol group and nifedipine group were 90.0%,87.5% and 81.8%,respectively.The antihypertensive effects in felodipine group and metoprolol group were better than in nifedipine group（P〈0.05）.The incidences of adverse drug reactions were 10.0%,12.5% and 15.2%,respectively.Average heart rate of 3 groups decreased to some extent,especially in felodipine group（P〈0.05）.The rate of creatinine clearance increased significantly（P〈0.05）,and left ventricular mass index（LVMI）decreased significantly（P〈0.05）.CONCLUSION：Felodipine and metoprolol are optimal choice for treatment of mild to moderate essential hypertension.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第46期4389-4391,共3页
China Pharmacy
关键词
轻、中度原发性高血压
非洛地平
美托洛尔
硝苯地平
疗效
Mild to moderate essential hypertension
Felodipine
Metoprolol
Nifedipine
Therapeutic effect
