摘要
目的:观察脉复生对动脉硬化闭塞症患者血脂及炎症细胞因子的影响,探讨其抗动脉粥样硬化的机制。方法:将120例患者采用随机对照原则分为2组,对照组60例,给予常规抗感染、控制血压、降糖、抗凝、改善循环、支持疗法等基础治疗。治疗组60例,在基础治疗上加脉复生口服。每日2次,每次50mL。在治疗前后分别抽取患者外周血,用于测定患者血脂6项(CHOL、TG、LDL、HDL、APOA、APOB)水平及CRP、IL-6、TNF-α,ICAM-1等细胞因子含量,比较自身前后变化及2组之间的差异。结果:治疗组治疗前、后相比,血脂水平有所下降(P<0.05),有统计学意义;治疗后,治疗组在降低TC、TG、LDL、APOB指标方面,与对照组比较,有统计学意义(P<0.05),但在升高HDL、APOA指标方面无明显统计学差异。脉复生治疗组内治疗前、后CRP、IL一6、TNF-a、ICAM-1相比均有显著性差异(P<0.01,P<0.05);治疗后,治疗组与对照组CRP、IL-6、TNF-a、ICAM-1相比均有显著性差异(P<0.05),治疗组优于对照组。结论:脉复生在调节血脂代谢,降低CRP等炎症因子,抗动脉血管炎症反应,抑制单核细胞与血管内皮细胞的黏附方面有良好作用,能抑制动脉硬化闭塞症的发生发展,对动脉硬化闭塞症具有较好的治疗效果。
Objective: To observe the impact of pulse resuscitation on the Lipids and inflammatory cytokines of arteriosclerosis obliterans patients and to explore its anti-atherosclerotic mechanisms.Methods: 120 patients were randomly divided into one treatment group and one control group,60 patients per group.The control group was treated with conventional basic treatment such as antibiotics,blood pressure control,blood glucose lowering,anti-coagulation,circulation improvement,supportive therapy.The treatment group was added with pulse resuscitation oral liquid besides the basic treatment,50ml/ twice daily.The peripheral bloods of the patients were collected before and after the treatment to determine their six blood lipid levels(CHOL,TG,LDL,HDL,APOA,APOB) and the content of their cytokines(CRP,IL-6,TNF-α,ICAM-1) and compare the differences and changes before and after the treatment.Results: The serum lipid levels of the patients in the treatment group decreased(P<0.05) statistically before and after treatment,and the lowering of TC,TG,LDL,APOB indicators showed statistical significance(P<0.05),but the increasing of HDL,APOA indicators showed no significantly statistical difference.The CRP,IL a 6,TNF-a,ICAM-1of the patients in the treatment group were significantly difference(P<0.01,P<0.05) before and after the treatment.The comparison of the CRP,IL a 6,TNF-a,ICAM-1of the two groups were significantly difference(P<0.05).The treatment group was better than the control group.Conclusion: The pulse resuscitation has a good effect on the regulation of lipid metabolism,the reduction of CRP and other inflammatory factors,anti-arterial inflammation,the inhibition of monocyte adhesion to vascular endothelial cells,and can inhibit the occurrence and development of arteriosclerosis obliterans,and has a better a therapeutic effect on arteriosclerosis obliterans disease.
出处
《云南中医中药杂志》
2011年第11期19-21,0,共3页
Yunnan Journal of Traditional Chinese Medicine and Materia Medica
基金
广州市卫生局中医科研课题
关键词
动脉硬化闭塞症
脉复生
血脂
炎症细胞因子
arterial occlusive disease
pulse resuscitation
lipids
inflammatory cytokines
