摘要
目的制备甲磺酸帕珠沙星凝胶,并考察其体外透皮吸收的效果。方法以卡波姆2020为基质,以离体小鼠皮肤作为透皮屏障,用改良Franz扩散池,双波长紫外分光光度法测定含量。结果凝胶为白色半透明细腻胶状,甲磺酸帕珠沙星在3μg/ml～10μg/ml浓度范围内呈良好线性关系(r=0.9993),平均回收率为100.3%,RSD为1.4%(n=9)。药物8h的累积透过量为130μg/cm2。结论工艺方法简单可行,制剂具有体外透皮吸收效果。
Objective To prepare pazufloxacin mesilate gel, and study its transdermal absorption in vitro. Methods Preparing carbomer2020 as a substrate, using in vitro mouse skin as a penetration barrier, modified Franz diffusion cell, and dual wavelength ultraviolet spectrophotometry to detcet the content. Results Gel was delicate white translucent jelly, pazufloxacin mesilate showed linear （ r =0.9993） in 3 μg/ml ~ 10 μg/ml concentration range, with recovery of 100.3%, RSD of 1.4%. The accumulation of 8 hours of drugs was 130 μg/cm2. Conclusion Process is simple and feasible with effective agents in vitro percutaneous absorption.
出处
《临床医学工程》
2011年第11期1703-1704,共2页
Clinical Medicine & Engineering
